华中科技大学学报（医学版）
華中科技大學學報（醫學版）
화중과기대학학보（의학판）
ACTA UNIVERSITATIS MEDICINAE TONGJI
2015年
4期
434-439
,共6页
丁洪波%高慧%严佩佩%王迪
丁洪波%高慧%嚴珮珮%王迪
정홍파%고혜%엄패패%왕적
血红素氧化酶-1%多囊卵巢综合征%胰岛素抵抗%氧化应激%炎症
血紅素氧化酶-1%多囊卵巢綜閤徵%胰島素牴抗%氧化應激%炎癥
혈홍소양화매-1%다낭란소종합정%이도소저항%양화응격%염증
heme oxygenase-1%polycystic ovary syndrome%insulin resistance%oxidative stress%inflammation
目的：探讨循环中血红素氧化酶‐1（HO‐1）是否参与了多囊卵巢综合征（PCOS）的发生。方法获得知情同意后，按照年龄和体重指数（BM I）匹配的原则，检测了80名PCOS患者和80名健康对照者的临床特征、外周血中激素水平以及糖脂代谢情况，提取并量化血清中HO‐1。分析 HO‐1与PCOS发病风险的关系，并界定其预测作用。结果PCOS组妇女较对照组存在显著增加的胰岛素抵抗（IR）、氧化应激（OS）和炎症状态，三者共同作用，对PCOS的病理生理过程形成一个恶性循环。复合模型的受试者工作特征曲线（ROC）分析显示，纳入或不纳入 HO‐1的曲线下面积分别为0.864（95％ CI 0.808～0.919）与0.953（95％ CI 0.923～0.982）（P＝0.0005）。结论血清 HO‐1可能参与了PCOS发生和发展过程，提示HO‐1可作为识别女性发生PCOS的一个早期生物学标志物。
目的：探討循環中血紅素氧化酶‐1（HO‐1）是否參與瞭多囊卵巢綜閤徵（PCOS）的髮生。方法穫得知情同意後，按照年齡和體重指數（BM I）匹配的原則，檢測瞭80名PCOS患者和80名健康對照者的臨床特徵、外週血中激素水平以及糖脂代謝情況，提取併量化血清中HO‐1。分析 HO‐1與PCOS髮病風險的關繫，併界定其預測作用。結果PCOS組婦女較對照組存在顯著增加的胰島素牴抗（IR）、氧化應激（OS）和炎癥狀態，三者共同作用，對PCOS的病理生理過程形成一箇噁性循環。複閤模型的受試者工作特徵麯線（ROC）分析顯示，納入或不納入 HO‐1的麯線下麵積分彆為0.864（95％ CI 0.808～0.919）與0.953（95％ CI 0.923～0.982）（P＝0.0005）。結論血清 HO‐1可能參與瞭PCOS髮生和髮展過程，提示HO‐1可作為識彆女性髮生PCOS的一箇早期生物學標誌物。
목적：탐토순배중혈홍소양화매‐1（HO‐1）시부삼여료다낭란소종합정（PCOS）적발생。방법획득지정동의후，안조년령화체중지수（BM I）필배적원칙，검측료80명PCOS환자화80명건강대조자적림상특정、외주혈중격소수평이급당지대사정황，제취병양화혈청중HO‐1。분석 HO‐1여PCOS발병풍험적관계，병계정기예측작용。결과PCOS조부녀교대조조존재현저증가적이도소저항（IR）、양화응격（OS）화염증상태，삼자공동작용，대PCOS적병리생리과정형성일개악성순배。복합모형적수시자공작특정곡선（ROC）분석현시，납입혹불납입 HO‐1적곡선하면적분별위0.864（95％ CI 0.808～0.919）여0.953（95％ CI 0.923～0.982）（P＝0.0005）。결론혈청 HO‐1가능삼여료PCOS발생화발전과정，제시HO‐1가작위식별녀성발생PCOS적일개조기생물학표지물。
Objective To examine whether heme oxygenase‐1(HO‐1)is involved in the etiology of polycystic ovary syn‐drome(PCOS).Methods After obtaining ethical approval and written informed consent ,80 PCOS patients and 80 healthy con‐trols(age range ,21-38 years ;BMI<30 kg/m2 ) ,matched for age and BMI ,were analyzed for their clinical characteristics ,hor‐mone levels and glycolipid metabolism in peripheral blood.Besides ,serum HO‐1 was extracted and determined.Additionally ,as‐sociations of HO‐1 with the prevalence and risk of PCOS were also analyzed.Results As compared with the controls ,women with PCOS were found to have a significantly increased insulin resistance ,oxidative stress and inflammation status ,eliciting a vi‐cious circle of effects on the pathophysiology of PCOS.The receiver‐operating characteristic curve(ROC)analysis yielded notably different discriminative value for PCOS ,with or without an addition of HO‐1[areas under the curves were 0.864(95% CI 0.808-0.919)vs.0.953(95% CI 0.923 -0.982);P=0.000 5].Conclusion Serum HO‐1 is possibly involved in the pathogenesis and development of PCOS ,indicating that HO‐1 can serve as an early biological marker of PCOS among young women.
