CAJ | 학술논문

microRNA-195(miR-195)是miR-15家族的成员之一,因其在多种疾病中高度异常表达,近年来受到广泛关注.它具有高度保守性,通过与靶基因的3'-UTR区的相应靶位点相结合,调控了细胞的增殖、分化、转移、凋亡等多种过程,进而参与了肿瘤、心血管、神经中枢等疾病的发生发展过程.同时,miR-195的表达还受上游转录因子及表观遗传修饰等调节.本文就miR-195的重要功能,上游调控因子与疾病的关系以及在疾病进程中的调控机制作一综述.
microRNA-195(miR-195)시miR-15가족적성원지일,인기재다충질병중고도이상표체,근년래수도엄범관주.타구유고도보수성,통과여파기인적3'-UTR구적상응파위점상결합,조공료세포적증식、분화、전이、조망등다충과정,진이삼여료종류、심혈관、신경중추등질병적발생발전과정.동시,miR-195적표체환수상유전록인자급표관유전수식등조절.본문취miR-195적중요공능,상유조공인자여질병적관계이급재질병진정중적조공궤제작일종술.
MiR-195,one member of the miR-15 family,has been paid great attention so far,because it shows highly abnormal expression in various diseases.MiR-195 is highly conserved,and can regulate cell cycle,cell differentiation,metastasis,apoptosis and other important cellular functions by regulating the 3 '-UTR of target genes.MiR-195 is involved in cancer,cardiovascular diseases,neurodegenerative diseases,etc.The expression of miR-195 is also regulated by transcription factors,epigenetic modifications,and so on.In the present paper,we review the important functions,upstream regulating factors,the relationship with diseases and mechanisms regulating the progress of miR-195-associated diseases.