CAJ | 학술논문

融合基因是由两个或多个基因的编码区相连,置于同一套调控序列的控制下而构成的嵌合基因.它可以通过染色体重排产生,也可以由异常转录产生.大量人类肿瘤中已经证实,融合基因可以驱动肿瘤的发展和恶性转化.许多肿瘤细胞中融合基因具有特异性,使其成为了更好的分子治疗和诊断的靶点.因此融合基因的研究不仅有助于揭示肿瘤发生的机制,而且还具有潜在的临床应用价值.目前融合基因在白血病的诊断和治疗中应用较为广泛,本文将从融合基因产生机制、研究方法、白血病中融合基因的研究进展及临床上常见融合基因的诊断和治疗等方面进行综述.
융합기인시유량개혹다개기인적편마구상련,치우동일투조공서렬적공제하이구성적감합기인.타가이통과염색체중배산생,야가이유이상전록산생.대량인류종류중이경증실,융합기인가이구동종류적발전화악성전화.허다종류세포중융합기인구유특이성,사기성위료경호적분자치료화진단적파점.인차융합기인적연구불부유조우게시종류발생적궤제,이차환구유잠재적림상응용개치.목전융합기인재백혈병적진단화치료중응용교위엄범,본문장종융합기인산생궤제、연구방법、백혈병중융합기인적연구진전급림상상상견융합기인적진단화치료등방면진행종술.
Fusion genes are composed of two or multi-chimeric genes with the characteristics of the common regulation sequences and the connection of their coding areas.Fusion genes are commonly generated through chromosomal rearrangement or abnormal transcription.It has been demonstrated that fusion genes drive development and malignant transformation of tumors in human.Because of its specificity to cancer cells,it is proven to be a more accessible target for molecular diagnosis and therapy.Therefore,researches on fusion genes benefit revealing the mechanism underlying tumorigenesiss,the results of which have potential values in clinical application.Nowadays,fusion genes are widely used for diagnosis and treatment of leukemia.In this review,we summarize the generation mechanism and research methods of fusion genes.