CAJ | 학술논문

乳腺癌是女性最常见的恶性肿瘤之一。早期诊断在乳腺癌的治疗中起着重要的作用。近年来随着表观遗传学的发展，为肿瘤的早期检测提供了新的方向。在表观遗传学中DNA甲基化与乳腺癌的关系的研究最为广泛，RASSF1A（ras相关区域家族基因1A）甲基化发生在乳腺癌的早期，与肿瘤的TNM分期、侵袭性以及预后有关。同时RASSF1A的甲基化是可逆的，因此RASSF1A甲基化的研究可为乳腺癌的早期诊断提供生物靶点，也为乳腺癌的治疗提供了一个潜在的研究方向。
유선암시녀성최상견적악성종류지일。조기진단재유선암적치료중기착중요적작용。근년래수착표관유전학적발전，위종류적조기검측제공료신적방향。재표관유전학중DNA갑기화여유선암적관계적연구최위엄범，RASSF1A（ras상관구역가족기인1A）갑기화발생재유선암적조기，여종류적TNM분기、침습성이급예후유관。동시RASSF1A적갑기화시가역적，인차RASSF1A갑기화적연구가위유선암적조기진단제공생물파점，야위유선암적치료제공료일개잠재적연구방향。
Breast cancer is one of the most common malignant tumors in women.Early diagnosis plays a very important role in the treatment of breast cancer.Recently,with the development of epigenetics,it gives us a new orientation for early detection for cancers.The most understood mechanism of epigenetics is DNA methyla-tion.Ras associated domain family 1A gene(RASSFlA)promoter methylation occurres in tumor′s early stage,and have a statistically concern with tumor′s TNM stage,invasiveness and outcomes.Moreover,DNA methylation can be reversed,so RASSF1A can be a promising candidate for early breast cancer detection biomarker,and can be a potential orientation for breast cancer treatment.