中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2015年
8期
565-568
,共4页
缴富斌%袁风仪%杨凡%徐飞%千年松
繳富斌%袁風儀%楊凡%徐飛%韆年鬆
격부빈%원풍의%양범%서비%천년송
胃肿瘤%癌胚抗原%预后
胃腫瘤%癌胚抗原%預後
위종류%암배항원%예후
Stomach neoplasms%Carcinoembryonic antigen%Prognosis
目的 评估胃癌患者术前腹腔冲洗液中癌胚抗原(CEA)mRNA的表达水平与手术预后的关系.方法 应用实时荧光定量聚合酶链反应检测68例胃癌患者及30例胃良性病患者术前腹腔冲洗液中CEA mRNA的表达水平.分析其表达水平与胃癌患者临床病理因素以及手术预后之间的关系.结果 胃癌患者术前腹腔冲洗液中CEA mRNA表达水平为1.74±0.25,胃良性病患者为0.19±0.04,两者比较差异有统计学意义(P＜0.05).胃癌患者术前腹腔冲洗液中CEA mRNA的表达水平与浸润深度、分化程度、淋巴结转移、远处转移和TNM分期有关(P＜0.05).胃癌患者术前腹腔冲洗液CEA mRNA低表达患者(34例),术居1年肿瘤复发转移率显著低于高表达患者(34例)[47.06％(16/34)比82.35％(28/34)],生存率显著高于高表达患者[79.41％(27/34)比55.88％(19/34)],差异均有统计学意义(P＜0.05).结论 胃癌患者术前腹腔冲洗液中CEA mRNA与胃癌的临床病理因素密切相关,其高表达提示胃癌患者手术预后差,可能是一个潜在的胃癌预后分子标志物.
目的 評估胃癌患者術前腹腔遲洗液中癌胚抗原(CEA)mRNA的錶達水平與手術預後的關繫.方法 應用實時熒光定量聚閤酶鏈反應檢測68例胃癌患者及30例胃良性病患者術前腹腔遲洗液中CEA mRNA的錶達水平.分析其錶達水平與胃癌患者臨床病理因素以及手術預後之間的關繫.結果 胃癌患者術前腹腔遲洗液中CEA mRNA錶達水平為1.74±0.25,胃良性病患者為0.19±0.04,兩者比較差異有統計學意義(P＜0.05).胃癌患者術前腹腔遲洗液中CEA mRNA的錶達水平與浸潤深度、分化程度、淋巴結轉移、遠處轉移和TNM分期有關(P＜0.05).胃癌患者術前腹腔遲洗液CEA mRNA低錶達患者(34例),術居1年腫瘤複髮轉移率顯著低于高錶達患者(34例)[47.06％(16/34)比82.35％(28/34)],生存率顯著高于高錶達患者[79.41％(27/34)比55.88％(19/34)],差異均有統計學意義(P＜0.05).結論 胃癌患者術前腹腔遲洗液中CEA mRNA與胃癌的臨床病理因素密切相關,其高錶達提示胃癌患者手術預後差,可能是一箇潛在的胃癌預後分子標誌物.
목적 평고위암환자술전복강충세액중암배항원(CEA)mRNA적표체수평여수술예후적관계.방법 응용실시형광정량취합매련반응검측68례위암환자급30례위량성병환자술전복강충세액중CEA mRNA적표체수평.분석기표체수평여위암환자림상병리인소이급수술예후지간적관계.결과 위암환자술전복강충세액중CEA mRNA표체수평위1.74±0.25,위량성병환자위0.19±0.04,량자비교차이유통계학의의(P＜0.05).위암환자술전복강충세액중CEA mRNA적표체수평여침윤심도、분화정도、림파결전이、원처전이화TNM분기유관(P＜0.05).위암환자술전복강충세액CEA mRNA저표체환자(34례),술거1년종류복발전이솔현저저우고표체환자(34례)[47.06％(16/34)비82.35％(28/34)],생존솔현저고우고표체환자[79.41％(27/34)비55.88％(19/34)],차이균유통계학의의(P＜0.05).결론 위암환자술전복강충세액중CEA mRNA여위암적림상병리인소밀절상관,기고표체제시위암환자수술예후차,가능시일개잠재적위암예후분자표지물.
Objective To investigate the correlation between expression of carcinoembryonic antigen (CEA) mRNA in preoperative peritoneal lavage fluid and prognosis of operation in patients with gastric cancer.Methods The expression levels of CEA mRNA in preoperative peritoneal lavage fluid of 68 patients with gastric cancer and 30 patients with gastric benign tumor were measured by reverse transcription polymerase chain reaction.The correlation between the expression level of CEA mRNA in preoperative peritoneal lavage fluid and clinicopathological features,prognosis of postoperative were analyzed.Results The expression level of CEA mRNA in preoperative peritoneal lavage fluid of patients with gastric cancre was 1.74 ± 0.25 and with gastric benign tumor was 0.19 ± 0.04,and there was statistical difference (P ＜ 0.05).The expression level of CEA mRNA in preoperative peritoneal lavage fluid had a correlation with the tumor infiltration depth,tumor differentiation,lymph node metastasis,distant metastasis and TNM stage (P ＜ 0.05).There was statistical difference in the recurrent / metastasis rate and survival rate 1 year after operation between low (34 cases) and higher (34 cases) expression level of CEA mRNA in preoperative peritoneal lavage fluid of gastric cancer patients:47.06％ (16/34) vs.82.35％ (28/34) and 79.41％ (27/34) vs.55.88％ (19/34),P ＜ 0.05.Conclusion The expression of CEA mRNA in preoperative peritoneal lavage fluid has close correlation with the clinicopathologic features,and the high expression of CEA mRNA indicats poor prognosis,indicating that CEA mRNA in preoperative peritoneal lavage fluid could be used as a prognostic marker in patients with gastric cancer.
