CAJ | 학술논문

目的：分析77例大肠癌同时性肝转移接受原发灶切除患者的临床病理特征和预后的关系。方法对77例经病理证实的大肠癌同时性肝转移接受原发灶切除患者的临床病理特征和预后的关系进行回顾性分析，采用Kaplan－Meier法进行生存分析，Log－rank检验比较组间生存差异。结果性别、肿瘤分化程度、TNM分期与预后显著相关（ P＜0．05）；而年龄、原发肿瘤部位、治疗方式、肝转移灶数目及是否合并肝外转移与预后无相关（ P＞0．05）。术前血清CEA和CA19－9与性别、肿瘤分化程度、TNM分期显著相关（P＜0．001）。 TNM分期与临床病理参数相关性分析结果显示仅原发灶手术方式与TNM分期相关（P＜0．05）。结论男性、肿瘤低分化及Ⅲ期是大肠癌同时性肝转移接受原发灶切除患者的预后不良因素。
목적：분석77례대장암동시성간전이접수원발조절제환자적림상병리특정화예후적관계。방법대77례경병리증실적대장암동시성간전이접수원발조절제환자적림상병리특정화예후적관계진행회고성분석，채용Kaplan－Meier법진행생존분석，Log－rank검험비교조간생존차이。결과성별、종류분화정도、TNM분기여예후현저상관（ P＜0．05）；이년령、원발종류부위、치료방식、간전이조수목급시부합병간외전이여예후무상관（ P＞0．05）。술전혈청CEA화CA19－9여성별、종류분화정도、TNM분기현저상관（P＜0．001）。 TNM분기여림상병리삼수상관성분석결과현시부원발조수술방식여TNM분기상관（P＜0．05）。결론남성、종류저분화급Ⅲ기시대장암동시성간전이접수원발조절제환자적예후불량인소。
Objective To analyze the clincopathological features and prognosis of 77 colorectal cancer patients with synchronous liver metastases after resection of the primary tumors.Methods Seventy seven colorec-tal cancer patients with synchronous liver metastases who underwent resection of the primary tumors and patholog-ical confirmed were enrolled in this retrospective study.The clincopathological features and prognosis were ana-lyzed.Kaplan-Meier method was used to analyze survival rate.The differences between survival curves were cal-culated by Log-rank test.Results The analysis showed that sex,tumor differentiation and TNM stage were as-sociated with prognosis(P<0.05).The analyses demonstrated no differences in age,primary tumor site,treat-ment,number of liver metastases and extrahepatic metastasis(P>0.05).There was a significant correlation be-tween CEA,CA19-9 level and gender,tumor differentiation and TNM stage(P<0.001)and the corresponding surgical procedure and TNM stage(P<0.05).Conclusion The analysis show that male,the low differentiation and stageⅢare poor prognosis factors.