CAJ | 학술논문

目的：探讨波形蛋白（ Vimentin）表达与结直肠癌临床病理特征及预后的关系。方法采用免疫组化方法对189例经病理组织学证实的结直肠癌组织进行Vimentin表达情况检测，分析其与结直肠癌临床病理特征及预后的关系。结果 Vimentin阳性表达与淋巴结转移（pN分期，P＝0．038）、TNM分期（P＝0．024）显著相关。生存分析表明，Vimentin阳性表达与结直肠癌不良预后显著相关（P＝0．016）。多因素分析发现，Vimentin表达是结直肠癌患者预后的一个独立因素（P＝0．026）。结论 Vimentin阳性表达与淋巴结转移和TNM分期显著相关，是影响其预后的独立因素。
목적：탐토파형단백（ Vimentin）표체여결직장암림상병리특정급예후적관계。방법채용면역조화방법대189례경병리조직학증실적결직장암조직진행Vimentin표체정황검측，분석기여결직장암림상병리특정급예후적관계。결과 Vimentin양성표체여림파결전이（pN분기，P＝0．038）、TNM분기（P＝0．024）현저상관。생존분석표명，Vimentin양성표체여결직장암불량예후현저상관（P＝0．016）。다인소분석발현，Vimentin표체시결직장암환자예후적일개독립인소（P＝0．026）。결론 Vimentin양성표체여림파결전이화TNM분기현저상관，시영향기예후적독립인소。
Objective Vimentin is the major protein consisting of intermediate filaments in normal and neoplastic mesenchymal cells.It has been regarded as a marker of epithelial mesenchymal transition( EMT) .How-ever,little is known about colorectal cancer( CRC) with Vimentin expression as a marker of EMT and prognosis. Methods We investigated the expression of Vimentin in CRC tissues and determined the correlations between Vimentin expression patterns and clinicopathologic characteristics and prognosis in CRC.In total,189 patients di-agnosed with CRC based on histopathological evaluation and those subjected to surgical resection at the Liaoning Province Cancer Hospital and Institute between 2000 and 2002 were examined.Immunohistochemical staining for Vimentin was performed for each specimen.Results Positive expression of Vimentin was significantly associated with the lymph node metastasis(pN stage,P=0.038),TNM stage(P=0.024).Survival analysis revealed that positive Vimentin expression was significantly related to poor prognosis ( P =0.016 ) .Multivariate analysis re-vealed that Vimentin expression was an independent prognostic factor for patient survival in colorectal cancer ( P=0.026) .Conclusion In conclusion,our data provide novel evidence for the clinical significance of Vimentin ex -pression as potential predictive biomarkers for identifying patients with lymph node metastasis or poor prognosis in CRC.