CAJ | 학술논문

目的：探讨CYP24A1基因多态位点对大肠癌发生和预后的影响。方法采用病例－对照研究方法对528例大肠癌患者和605例对照进行维生素 D 代谢相关基因CYP24 A1的 Rs4809957和Rs2762934多态位点与大肠癌发病关系的分析，并探讨多态位点与饮食因素的联合作用和交互作用与大肠癌发生的关系；随访317例大肠癌患者，探讨多态位点与大肠癌预后的关系。结果 Rs4809957和Rs2762934多态位点与饮食因素的联合作用与大肠癌的发病有关。对于Rs4809957多态位点，与GG／GA基因型相比，携带AA基因型的大肠癌患者、结肠癌患者和直肠癌患者的预后均较差（ Log－rank检验分别为P＝0．01，P＝00．1，P＝0．02）；与野生型GG相比，AA基因型可导致大肠癌患者（ HR＝2．35，95％ CI：1．28～4．30）、结肠癌患者（ HR＝2．37，95％ CI：1．09～5．14）、直肠癌患者（HR ＝2．11，95％CI：1．11～4．01）预后不良。结论 CYP24A1基因Rs4809957和Rs2762934多态位点与饮食因素的联合作用与大肠癌的易感性有关，且Rs4809957多态位点可能会影响大肠癌患者的预后。
목적：탐토CYP24A1기인다태위점대대장암발생화예후적영향。방법채용병례－대조연구방법대528례대장암환자화605례대조진행유생소 D 대사상관기인CYP24 A1적 Rs4809957화Rs2762934다태위점여대장암발병관계적분석，병탐토다태위점여음식인소적연합작용화교호작용여대장암발생적관계；수방317례대장암환자，탐토다태위점여대장암예후적관계。결과 Rs4809957화Rs2762934다태위점여음식인소적연합작용여대장암적발병유관。대우Rs4809957다태위점，여GG／GA기인형상비，휴대AA기인형적대장암환자、결장암환자화직장암환자적예후균교차（ Log－rank검험분별위P＝0．01，P＝00．1，P＝0．02）；여야생형GG상비，AA기인형가도치대장암환자（ HR＝2．35，95％ CI：1．28～4．30）、결장암환자（ HR＝2．37，95％ CI：1．09～5．14）、직장암환자（HR ＝2．11，95％CI：1．11～4．01）예후불량。결론 CYP24A1기인Rs4809957화Rs2762934다태위점여음식인소적연합작용여대장암적역감성유관，차Rs4809957다태위점가능회영향대장암환자적예후。
Objective To explore the associations between polymorphisms in CYP24A1 gene and the risk and prognosis of colorectal cancer ( CRC) .Methods A case-control study consisting of 528 CRC patients and 605 cancer free controls and a follow up study with 317 cases were conducted to explore the associations be-tween two polymorphisms in CYP24A1 and the risk and prognosis of CRC,as well as the combinations and inter-actions of polymorphisms with dietary factors on CRC risk.Results Although there was no association between polymorphisms in CYP24A1 and the risk of CRC,significant combinative effects between polymorphisms and diet-ary factors on CRC risk were observed.For Rs4809957 polymorphism,the prognosis of AA genotype carriers was worse than GG/GA carriers in CRC,colon cancer and rectal cancer(Log-rank test P=0.01,P=0.01,P=0.02,respectively).Compared with GG genotype,AA genotype carriers of Rs4809957 polymorphism had worse prognosis in CRC(HR =2.35,95%CI =1.28~4.30),colon caner(HR =2.37,95% CI =1.09~5.14) and rectal cancer(HR =2.11,95% CI =1.11~4.01).Conclusion The combinations of the polymorphisms in CYP24A1 gene with dietary factors are associated with the susceptibility of CRC,and Rs4809957 polymorphism may lead to a worse prognosis of CRC.