CAJ | 학술논문

目的：探讨大光斑低能量Q开关Nd：YAG激光联合化瘀祛斑胶囊治疗黄褐斑的疗效及安全性。方法：选取笔者科室2013年1月-2015年5月收治的女性黄褐斑患者90例，随机分为治疗组和对照组。对照组：给予患者Q开关Nd：YAG激光治疗，波长1064nm，光斑6mm，能量1.5～2.5J/cm2，每周1次，连续治疗8周后改为每2周1次再治疗4周，10次为1个疗程,共治疗12周；治疗组：在对照组治疗基础上加服化瘀祛斑胶囊，5片/次,2次/日，连续服用12周。分别于治疗8周和12周时评价疗效。结果：治疗8周时，治疗组有效率66.67%,对照组62.22%，两组比较差异无显著性(P＞0.05)；12周时，治疗组有效率86.67%,对照组68.89%,两组比较差异有显著性(P＜0.05)。结论：大光斑低能量Q开关Nd：YAG激光联合化瘀祛斑胶囊治疗黄褐斑安全、有效，值得临床推广应用。
목적：탐토대광반저능량Q개관Nd：YAG격광연합화어거반효낭치료황갈반적료효급안전성。방법：선취필자과실2013년1월-2015년5월수치적녀성황갈반환자90례，수궤분위치료조화대조조。대조조：급여환자Q개관Nd：YAG격광치료，파장1064nm，광반6mm，능량1.5～2.5J/cm2，매주1차，련속치료8주후개위매2주1차재치료4주，10차위1개료정,공치료12주；치료조：재대조조치료기출상가복화어거반효낭，5편/차,2차/일，련속복용12주。분별우치료8주화12주시평개료효。결과：치료8주시，치료조유효솔66.67%,대조조62.22%，량조비교차이무현저성(P＞0.05)；12주시，치료조유효솔86.67%,대조조68.89%,량조비교차이유현저성(P＜0.05)。결론：대광반저능량Q개관Nd：YAG격광연합화어거반효낭치료황갈반안전、유효，치득림상추엄응용。
Objective To evaluate the efficacy and safety of low-fluence and large spot-size 1 064nm Q-switched Nd:YAG laser combined with HuayuQuban capsule for the treatment of melasma. Methods The ninety female patients with melasma were enrolled in study from January 2013 to May 2015 in our hospital,and randomly divided into the treatment group and control group.Forty-five patients of control group were treated once a week for 8 weeks and then two weeks a time for 4 weeks by 1 064nm Q-switched Nd:YAG laser at fluences of 1.5-2.5J/cm2 and a spot size of 6mm,the treatment group was given HuayuQuban capsule 5 tablets/time,2 times a day on the basis of control group.Each group received treatment for 12 weeks.Clinical efficacy were evaluated after 8 and 12 weeks of treatment. Results After 8 weeks of treatment,the markedly effective rate of treatment group was 66.67%and that of control group was 62.22%.There was no significant difference(P>0.05).After 12 weeks of treatment,the markedly effective rate of treatment group was 86.67%and that of control group was 68.89%.The markedly effective rate of control group in 12th week was significantly lower than that of treatment group.The difference was statistically significant(P<0.05). Conclusion The low-fluenee,1arge spot-size,1 064nm Q-switched Nd:YAG laser combined with HuayuQuban capsule is a safe and effective treatment modality for melasma.