中国美容医学
中國美容醫學
중국미용의학
CHINESE JOURNAL OF AESTHETIC MEDICINE
2015年
16期
32-35
,共4页
骨桥蛋白%CD44v6%恶性黑素瘤%免疫组织化学
骨橋蛋白%CD44v6%噁性黑素瘤%免疫組織化學
골교단백%CD44v6%악성흑소류%면역조직화학
osteopontin%CD44v6%melanoma malignant%immunohistochemistry
目的：探讨骨桥蛋白(OPN)和CD44v6在恶性黑素瘤中的表达特点及其生物学意义。方法：应用免疫组化法分别检测16例恶性黑素瘤患者皮损及12例良性黑素痣中OPN和CD44v6的表达情况。结果：OPN和CD44v6在恶性黑素瘤中阳性表达分别为87.5%%和75%，显著高于良性黑素痣的16.7%和0（P＜0.01）。OPN和CD44v6呈正相关关系（r=0.69，P＜0.05）。恶性黑素瘤中OPN和CD44v6阳性表达可能与其高转移性能有关(P＜0.05)。结论：OPN和CD44v6的高表达在恶性黑素瘤的发生和转移中可能起着重要的协同作用。
目的：探討骨橋蛋白(OPN)和CD44v6在噁性黑素瘤中的錶達特點及其生物學意義。方法：應用免疫組化法分彆檢測16例噁性黑素瘤患者皮損及12例良性黑素痣中OPN和CD44v6的錶達情況。結果：OPN和CD44v6在噁性黑素瘤中暘性錶達分彆為87.5%%和75%，顯著高于良性黑素痣的16.7%和0（P＜0.01）。OPN和CD44v6呈正相關關繫（r=0.69，P＜0.05）。噁性黑素瘤中OPN和CD44v6暘性錶達可能與其高轉移性能有關(P＜0.05)。結論：OPN和CD44v6的高錶達在噁性黑素瘤的髮生和轉移中可能起著重要的協同作用。
목적：탐토골교단백(OPN)화CD44v6재악성흑소류중적표체특점급기생물학의의。방법：응용면역조화법분별검측16례악성흑소류환자피손급12례량성흑소지중OPN화CD44v6적표체정황。결과：OPN화CD44v6재악성흑소류중양성표체분별위87.5%%화75%，현저고우량성흑소지적16.7%화0（P＜0.01）。OPN화CD44v6정정상관관계（r=0.69，P＜0.05）。악성흑소류중OPN화CD44v6양성표체가능여기고전이성능유관(P＜0.05)。결론：OPN화CD44v6적고표체재악성흑소류적발생화전이중가능기착중요적협동작용。
Objective To study the expression and biological significance of osteopontin(OPN)and CD44v6 in human malignant melanoma. Methods The distribution and expression of OPN and CD44v6 was detected in 16 malignant melanoma patients and in 12 patients with benign melanocytic nevi by immunohistochemistry. Results The positive expression rates of OPN and CD44v6 in malignant melanoma were 87.5%and 75%,respectively.The expression of OPN and CD44v6 was significantly higher in malignant melanoma than that in benign melanocytic nevi tissues(P<0.01)). There was a positive correlation between OPN and CD44v6(r=0.69,P<0.05).The positive rates of OPN and CD44v6 were associated with metastasis(P<0.05). Conclusion Overexpression of OPN and CD44v6 may contribute to the development and metastasis of malignant melanoma.
