中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2015年
8期
1207-1211
,共5页
李晶%胡敏%黄佳斯%陈若虹
李晶%鬍敏%黃佳斯%陳若虹
리정%호민%황가사%진약홍
载脂蛋白A-Ⅰ/代谢%脱辅蛋白质(a)/代谢%载脂蛋白B类/代谢%高半胱氨酸/代谢%C反应蛋白质/代谢%数据收集
載脂蛋白A-Ⅰ/代謝%脫輔蛋白質(a)/代謝%載脂蛋白B類/代謝%高半胱氨痠/代謝%C反應蛋白質/代謝%數據收集
재지단백A-Ⅰ/대사%탈보단백질(a)/대사%재지단백B류/대사%고반광안산/대사%C반응단백질/대사%수거수집
Apolipoprotein A-Ⅰ/ME%Apoprotein (a)/ME%Apolipoproteins B/ME%Homocysteine/ME%C-reactive protein/ME%Data Collection
目的 了解湖南地区成人载脂蛋白及相关指标水平及异常发生率,为建立湖南地区正常参考区间提供依据.方法 选取2014年8月至2014年10月中南大学湘雅二医院健康体检者341例,其中男239例,女102例,年龄22～77岁.按年龄分为四组,A组:22 ～42(35.56 ±5.39)岁;B组:43 ～48(45.59±1.59)岁;C组:49 ～55(51.19±1.81)岁;D组:56 ～ 77(63.08 ±5.84)岁.采用全自动生化分析仪测定载脂蛋白AI (apoAI)、载脂蛋白B(apoB)、载脂蛋白a[Lp(a)]、超敏C反应蛋白(hs-CRP)和同型半胱氨酸(HCY).比较不同年龄以及各组不同性别间各指标水平和异常发生率的差异.结果 与男性总体水平比较,女性apoAI及Lp(a)平均水平升高(P＜0.05),而apoB、hs-CRP及HCY均降低(P＜0.05).四个年龄组人群的apoB和hs-CRP在总体上差异有统计学意义(P＜0.05);各个项目的异常率差异均无统计学意义(P＞0.05).A、B、D组女性的高HCY发生率低于男性(P＜0.05).结论 所有指标均存在性别差异,apoAI水平随年龄改变变化不大,apoB与年龄有一定关系,Lp(a)、hs-CRP和HCY不随年龄变化而改变.男性总体HCY水平更高,且比女性更易发生高HCY血症.
目的 瞭解湖南地區成人載脂蛋白及相關指標水平及異常髮生率,為建立湖南地區正常參攷區間提供依據.方法 選取2014年8月至2014年10月中南大學湘雅二醫院健康體檢者341例,其中男239例,女102例,年齡22～77歲.按年齡分為四組,A組:22 ～42(35.56 ±5.39)歲;B組:43 ～48(45.59±1.59)歲;C組:49 ～55(51.19±1.81)歲;D組:56 ～ 77(63.08 ±5.84)歲.採用全自動生化分析儀測定載脂蛋白AI (apoAI)、載脂蛋白B(apoB)、載脂蛋白a[Lp(a)]、超敏C反應蛋白(hs-CRP)和同型半胱氨痠(HCY).比較不同年齡以及各組不同性彆間各指標水平和異常髮生率的差異.結果 與男性總體水平比較,女性apoAI及Lp(a)平均水平升高(P＜0.05),而apoB、hs-CRP及HCY均降低(P＜0.05).四箇年齡組人群的apoB和hs-CRP在總體上差異有統計學意義(P＜0.05);各箇項目的異常率差異均無統計學意義(P＞0.05).A、B、D組女性的高HCY髮生率低于男性(P＜0.05).結論 所有指標均存在性彆差異,apoAI水平隨年齡改變變化不大,apoB與年齡有一定關繫,Lp(a)、hs-CRP和HCY不隨年齡變化而改變.男性總體HCY水平更高,且比女性更易髮生高HCY血癥.
목적 료해호남지구성인재지단백급상관지표수평급이상발생솔,위건립호남지구정상삼고구간제공의거.방법 선취2014년8월지2014년10월중남대학상아이의원건강체검자341례,기중남239례,녀102례,년령22～77세.안년령분위사조,A조:22 ～42(35.56 ±5.39)세;B조:43 ～48(45.59±1.59)세;C조:49 ～55(51.19±1.81)세;D조:56 ～ 77(63.08 ±5.84)세.채용전자동생화분석의측정재지단백AI (apoAI)、재지단백B(apoB)、재지단백a[Lp(a)]、초민C반응단백(hs-CRP)화동형반광안산(HCY).비교불동년령이급각조불동성별간각지표수평화이상발생솔적차이.결과 여남성총체수평비교,녀성apoAI급Lp(a)평균수평승고(P＜0.05),이apoB、hs-CRP급HCY균강저(P＜0.05).사개년령조인군적apoB화hs-CRP재총체상차이유통계학의의(P＜0.05);각개항목적이상솔차이균무통계학의의(P＞0.05).A、B、D조녀성적고HCY발생솔저우남성(P＜0.05).결론 소유지표균존재성별차이,apoAI수평수년령개변변화불대,apoB여년령유일정관계,Lp(a)、hs-CRP화HCY불수년령변화이개변.남성총체HCY수평경고,차비녀성경역발생고HCY혈증.
Objective To investigate the levels and the abnormal incidences of apolipoprotein and other related indicators in health people in Hunan province,and to provide data for establishment of reference intervals in Hunan province.Methods The people with physical examination (n =341) were chosen from the Second Xiangya Hospital of Central South University during August 2014 ～ October 2014 (male,n =239;female,n =102) with age from 22 to 77 years old.All people were divided into 4 groups according to their age:group A aged from 22 to 42 (35.56 ± 5.39),group B aged from 43 to 48 (45.59 ± 1.59),group C aged from 49 to 55 (51.19 ± 1.81),and group D aged from 56 to 77 (63.08 ±5.84).The levels of apoAI,apoB,Lp (a),hypersensitive C-reactive protein (hs-CRP),and homocysteine (HCY) were detected with automatic biochemical analyzer,and were compared among different age groups and between male and female in each age group.Results Compared to male,the average levels of apoAI,and Lp (a) were significantly increased (P ＜0.05),and apoB,hs-CRP,and Hcy were significantly decreased (P ＜ 0.05) in the female.The levels of apoB,and hs-CRP were significantly different among 4 age groups (P ＜ 0.05).The abnormal rate in each index among 4 age groups was not significantly different (P ＞ 0.05).For groups A,B and D,the abnormal rate of Hcy was significant higher in male relative to female (P ＜ 0.05).Conclusions All the indices have significant difference between male and female (P ＜0.05).The levels of apoAI,Lp (a),hs-CRP,and Hcy do not change with the changed age.However,apoB has a certain relationship with age.The level and abnormal rate of Hcy are significantly higher in male relative to female.
