CAJ | 학술논문

目的：探究经导管动脉化学栓塞(transcatheter arterial chemoembolization,TACE)联合索拉非尼治疗对中晚期肝细胞癌患者血清血管内皮生长因子(VEGF)水平及疗效的影响。方法选取2009年1月至2014年12月于我院就诊的50例确诊为中晚期肝细胞癌(HCC)患者为研究对象,按照治疗方法不同分为研究组(n =22例)和对照组(n =28例)。研究组患者采用 TACE 联合索拉非尼治疗,对照组患者单独使用 TACE 治疗,治疗前后经酶联免疫吸附实验(ELISA)法检测血清 VEGF 水平,比较分析两组患者的近期疗效,不良反应率及1年内复发率及病死率。结果研究组患者的治疗效果明显优于对照组(P <0.05)；治疗前两组患者的血清 VEGF 水平差异无统计学意义(P >0.05),治疗后研究组患者血清 VEGF 水平明显低于对照组(P <0.05)；研究组患者在腹泻、手足反应、脱发等不良反应方面明显多于对照组(P <0.05),而其他不良反应两组患者差异无统计学意义(P >0.05)；研究组患者1年内的复发率和病死率显著低于对照组(P <0.05)。结论 TACE 联合索拉非尼治疗中晚期肝细胞癌可显著降低患者的VEGF 水平,同时疗效明显,复发少,值得临床推广。
목적：탐구경도관동맥화학전새(transcatheter arterial chemoembolization,TACE)연합색랍비니치료대중만기간세포암환자혈청혈관내피생장인자(VEGF)수평급료효적영향。방법선취2009년1월지2014년12월우아원취진적50례학진위중만기간세포암(HCC)환자위연구대상,안조치료방법불동분위연구조(n =22례)화대조조(n =28례)。연구조환자채용 TACE 연합색랍비니치료,대조조환자단독사용 TACE 치료,치료전후경매련면역흡부실험(ELISA)법검측혈청 VEGF 수평,비교분석량조환자적근기료효,불량반응솔급1년내복발솔급병사솔。결과연구조환자적치료효과명현우우대조조(P <0.05)；치료전량조환자적혈청 VEGF 수평차이무통계학의의(P >0.05),치료후연구조환자혈청 VEGF 수평명현저우대조조(P <0.05)；연구조환자재복사、수족반응、탈발등불량반응방면명현다우대조조(P <0.05),이기타불량반응량조환자차이무통계학의의(P >0.05)；연구조환자1년내적복발솔화병사솔현저저우대조조(P <0.05)。결론 TACE 연합색랍비니치료중만기간세포암가현저강저환자적VEGF 수평,동시료효명현,복발소,치득림상추엄。
ABSTRACT:Objective To investigate the effect of transcatheter arterial chemoembolization (TACE)combined with Sola Fini in the treatment of advanced hepatocellular carcinoma on serum vascular endothelial growth factor (VEGF)of patients and the efficacy.Methods Fifty cases who were diagnosed as hepatocellular carcinoma and accepted treatment in our hospital from January 2009 to December 2014 were divided into study group and control group.The study group were given by TACE combined with Sola Fini,while the control group received TACE only. The level of serum VEGF was detected before and after treatment by ELISA.The difference of recent curative effect, adverse reactions and recurrence rate were analysed within one year between two groups.Results Before treatment, the level of serum VEGF showed no significant difference between two groups(P >0.05).After treatment,the level of serum VEGF in the study group was significantly lower than that of control group(P <0.05).The curative effect of study group was significantly better than that of control group (P <0.05 ).The adverse reactions of study group such as diarrhea,hand foot reaction,alopecia were significantly obvious than those of the control group (P <0.05), and other adverse reactions of the two groups had no significant difference (P >0.05).Recurrence rate and mortality rate within one year in study group were significantly lower than those in control group (P < 0.05 ).Conclusion TACE combined with Sola Fini in the treatment of late stage of hepatocellular carcinoma can significantly decrease the level of VEGF in patients,and have obvious curative effect and low recurrence rate,which deserved the clinical expansion.