CAJ | 학술논문

目的：观察咖啡酸片对肝硬化患者合并脾功能亢进所致白细胞、血小板数量减少的临床疗效。方法选择肝硬化伴脾功能亢进患者，分为代偿期70例和失代偿期32例两组，均给予咖啡酸片0.3 g/次，每日3次口服，共3个月，观察治疗前后患者白细胞、血小板计数变化。结果咖啡酸片可提高代偿期肝硬化及失代偿期肝硬化患者白细胞数，总有效率分别为75.7%(53/70)和71.9%(23/32)；也可提高代偿期肝硬化及失代偿期肝硬化患者血小板数，总有效率分别为91.4%(64/70)和84.4%(27/32)。结论咖啡酸片对代偿期、失代偿期肝硬化并脾功能亢进患者的白细胞、血小板计数均有提高作用，尤其代偿期肝硬化患者，疗效更好。
목적：관찰가배산편대간경화환자합병비공능항진소치백세포、혈소판수량감소적림상료효。방법선택간경화반비공능항진환자，분위대상기70례화실대상기32례량조，균급여가배산편0.3 g/차，매일3차구복，공3개월，관찰치료전후환자백세포、혈소판계수변화。결과가배산편가제고대상기간경화급실대상기간경화환자백세포수，총유효솔분별위75.7%(53/70)화71.9%(23/32)；야가제고대상기간경화급실대상기간경화환자혈소판수，총유효솔분별위91.4%(64/70)화84.4%(27/32)。결론가배산편대대상기、실대상기간경화병비공능항진환자적백세포、혈소판계수균유제고작용，우기대상기간경화환자，료효경호。
Objective To investigate the clinical effect of caffeic acid tablets(CFA)in thrombocytopenia and leucopenia caused by hypersplenism with liver cirrhosis.Methods 102 patients with liver cirrhosis and hypersplenism were enrolled in this study,including 70 patients with compensated cirrhosis and 32 patients with decompensated cirrhosis.All of the patients were assigned to receive CFA (0.3)tid orally,then the number changes of platelet and leukocyte after 3 months of treatment were evaluated.Results CFA increased the number of leukocytes in 75.5%patients with compensated cirrhosis,while 71.9% patients with decompensated cirrhosis.We also found that CFA could increase the number of platelets in 91.4% patients with compensated cirrhosis,while 84.4% patients with decompensated cirrhosis.Conclusion CFA could increase the number of leukocytes and platelets in both compensated and decompensated cirrhotic patients,especially in the compensated cirrhotic patients.