中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2015年
19期
2-4
,共3页
阿尔茨海默病%院内肺部感染%病原菌%耐药性
阿爾茨海默病%院內肺部感染%病原菌%耐藥性
아이자해묵병%원내폐부감염%병원균%내약성
Alzheimer's disease%Hospital-acquired pulmonary infection%Pathogenic bacteria%Drug resistance
目的：探讨老年阿尔茨海默病（AD）患者院内肺部感染病原菌分布及耐药性，为临床合理使用抗生素提供依据。方法对2011‐01—2013‐10在我院神经内科住院的126例老年阿尔茨海默病患者痰培养及药物敏感试验结果进行回顾性分析。结果痰培养共检出134株病原菌，其中 G －菌80株（59.7％），G ＋菌37株（27.6％），真菌17株（12.7％）。 G －茵主要有肺炎克雷伯茵、绿脓假单胞杆菌、肝炎杆茵及大肠杆茵；G ＋菌46株（34.8％），G ＋菌主要有金黄色葡萄球菌、化脓性链球菌及表皮葡萄球菌；真菌13株（9.9％）。药物敏感试验结果显示：G －菌对泰能最为敏感，对头孢噻肟、对氨苄西林、庆大霉素、哌拉西林和环丙沙星耐药性比较高；G ＋菌对万古霉素最为敏感，对青霉素 G 、四环素药性比较高。结论老年 AD 患者院内肺部感染病原菌以 G －菌为主，大部分出现多重耐药现象，细菌耐药性监测对指导临床合理用药具有重要意义。
目的：探討老年阿爾茨海默病（AD）患者院內肺部感染病原菌分佈及耐藥性，為臨床閤理使用抗生素提供依據。方法對2011‐01—2013‐10在我院神經內科住院的126例老年阿爾茨海默病患者痰培養及藥物敏感試驗結果進行迴顧性分析。結果痰培養共檢齣134株病原菌，其中 G －菌80株（59.7％），G ＋菌37株（27.6％），真菌17株（12.7％）。 G －茵主要有肺炎剋雷伯茵、綠膿假單胞桿菌、肝炎桿茵及大腸桿茵；G ＋菌46株（34.8％），G ＋菌主要有金黃色葡萄毬菌、化膿性鏈毬菌及錶皮葡萄毬菌；真菌13株（9.9％）。藥物敏感試驗結果顯示：G －菌對泰能最為敏感，對頭孢噻肟、對氨芐西林、慶大黴素、哌拉西林和環丙沙星耐藥性比較高；G ＋菌對萬古黴素最為敏感，對青黴素 G 、四環素藥性比較高。結論老年 AD 患者院內肺部感染病原菌以 G －菌為主，大部分齣現多重耐藥現象，細菌耐藥性鑑測對指導臨床閤理用藥具有重要意義。
목적：탐토노년아이자해묵병（AD）환자원내폐부감염병원균분포급내약성，위림상합리사용항생소제공의거。방법대2011‐01—2013‐10재아원신경내과주원적126례노년아이자해묵병환자담배양급약물민감시험결과진행회고성분석。결과담배양공검출134주병원균，기중 G －균80주（59.7％），G ＋균37주（27.6％），진균17주（12.7％）。 G －인주요유폐염극뢰백인、록농가단포간균、간염간인급대장간인；G ＋균46주（34.8％），G ＋균주요유금황색포도구균、화농성련구균급표피포도구균；진균13주（9.9％）。약물민감시험결과현시：G －균대태능최위민감，대두포새우、대안변서림、경대매소、고랍서림화배병사성내약성비교고；G ＋균대만고매소최위민감，대청매소 G 、사배소약성비교고。결론노년 AD 환자원내폐부감염병원균이 G －균위주，대부분출현다중내약현상，세균내약성감측대지도림상합리용약구유중요의의。
Objective To investigate pathogenic bacteria distribution and drug resistance for hospital‐acquired pulmonary infection among patients with elderly Alzheimer's disease (AD) and provide a basis for the rational use of antibiotics clinically.Methods A retrospective analysis was made of sputum culture and drug sensitivity test results among 126 AD patients hospi‐talized in neurology of our hospital from January 2011 to October 2013. Results A total of 134 pathogenic bacterial strains were detected in the sputum culture ,including 80 G - bacterial strains ,accounting for 59.7% ,37 G + bacterial strains ,account‐ing for 27.6% and 17 fungi strains ,accounting for 12.7% . G - bacteria mainly included pneumonia klebsiella ,green pus pseud‐omonas ,hepatitis and Escherichia coli. There were 46 G + bacterial strains ,accounting for 34.8% ,mainly including staphylo‐coccus aureus ,pyogenic streptococcus and staphylococcus epidermidis. There were 13 fungi strains ,accounting for 9.9% . Drug sensitivity test results showed that G - bacteria were the most sensitive to Tienam and highly resistant to cefotaxime ,am‐picillin ,gentamicin ,piperacillin and ciprofloxacin. G + bacteria were the most sensitive to vancomycin and highly resistant to Penicillin G and tetracycline. Conclusion Pathogenic bacteria for hospital‐acquired pulmonary infection among AD patients are mainly G - bacteria and mostly multi‐drug resistant. Drug resistance surveillance for bacteria is of great significance for the ra‐tional use of drugs clinically.
