CAJ | 학술논문

1例45岁膜性肾病患者,因应用免疫抑制剂出现肺部感染,先后多次调整抗感染药物治疗方案.在应用伏立康唑治疗2 d后患者出现色视、血糖升高不良反应,同时他克莫司血药浓度以及国际标准化比值(INR)升高.在治疗过程中,药师协助医师及时评估免疫抑制方案及抗感染方案,在免疫抑制药物与抗感染药物的调整、药物相互作用的分析、不良反应原因解析等方面进行药学监护.经对症治疗后,患者病情好转出院.
1례45세막성신병환자,인응용면역억제제출현폐부감염,선후다차조정항감염약물치료방안.재응용복립강서치료2 d후환자출현색시、혈당승고불량반응,동시타극막사혈약농도이급국제표준화비치(INR)승고.재치료과정중,약사협조의사급시평고면역억제방안급항감염방안,재면역억제약물여항감염약물적조정、약물상호작용적분석、불량반응원인해석등방면진행약학감호.경대증치료후,환자병정호전출원.
One 45-year-old patient with membranous nephropathy got pulmonary infection due to immunosuppressant, and the anti-infection treatments were adjusted repeatedly. After 2-day treatment of voriconazole, the adverse drug reactions of chromatopsia, hyperglycemia occurred, with the increase of tacrolimus concentration and the INR. During the treatment, pharmacists assisted the physicians in the assessment of immunosuppressive therapy and the anti-infection treatment. And the pharmacists took pharmaceutical cares on adjusting immunosuppressive and anti-infection drugs, analyzing drug interaction and the reasons of ADR. The patient with better condition was discharged after symptomatic treatment.