CAJ | 학술논문

目的：探究急性重度有机磷农药中毒患者中使用前列地尔注射液治疗的心肌保护效果，为提高患者的治疗质量提供指导依据。方法选择2012年7月至2014年4月我院收治的急性重度有机磷农药中毒患者106例，采用随机数字表法分成观察组与对照组，每组均53例，对照组进行常规治疗及阿托品、解磷定等特效治疗，观察组在对照组基础上使用前列地尔注射液治疗，比较两组患者的治疗效果。结果观察组治疗总有效率94.3%(50/53)，显著高于对照组71.7%(38/53)，差异有统计学意义(P <0.01)；观察组治疗3天后、7天后的肌钙蛋白 I(cTn-I)、肌酸激酶同工酶(CK-MB)等指标水平及心电图异常发生率均显著低于对照组患者，且观察组患者左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室质量指数(LVMI)等心脏形态结构指标水平均显著低于对照组患者，差异有统计学意义(P <0.05)；两组患者均未发生严重的不良反应症状。结论在急性重度有机磷农药中毒患者中使用前列地尔注射液治疗，能够有效保护患者的心肌功能，药疗安全性高，具有较高的临床推广价值。
목적：탐구급성중도유궤린농약중독환자중사용전렬지이주사액치료적심기보호효과，위제고환자적치료질량제공지도의거。방법선택2012년7월지2014년4월아원수치적급성중도유궤린농약중독환자106례，채용수궤수자표법분성관찰조여대조조，매조균53례，대조조진행상규치료급아탁품、해린정등특효치료，관찰조재대조조기출상사용전렬지이주사액치료，비교량조환자적치료효과。결과관찰조치료총유효솔94.3%(50/53)，현저고우대조조71.7%(38/53)，차이유통계학의의(P <0.01)；관찰조치료3천후、7천후적기개단백 I(cTn-I)、기산격매동공매(CK-MB)등지표수평급심전도이상발생솔균현저저우대조조환자，차관찰조환자좌심실서장말기내경(LVEDD)、좌심실수축말기내경(LVESD)、좌심실질량지수(LVMI)등심장형태결구지표수평균현저저우대조조환자，차이유통계학의의(P <0.05)；량조환자균미발생엄중적불량반응증상。결론재급성중도유궤린농약중독환자중사용전렬지이주사액치료，능구유효보호환자적심기공능，약료안전성고，구유교고적림상추엄개치。
Objective To explore the myocardial protective effect of alprostadil injection in patients with acute severe organophosphorus pesticide poisoning and to provide data for improving the quality of patient care.Methods A total of 106 patients with severe organic phosphorus pesticide poisoning were randomly divided into observation group (53 cases)and control group (53 cases).Control group was treated with conventional treatment,atropine and pralidoxime and observation group was treated conventional treatment,atropine,pralidoxime and alprostadil injection. Treatment effect was sobserved between two groups.Results Total effective rate of 94.3% in the observation group was significantly higher than that of 71.7% in control group (P < 0.01 ).On the third and seventh day after treatment,the levels of cTn-I,and CK-MB and the incidence of abnormal electrocardiogram were significantly lower in observation group than in control group,and LVEDD,LVESD,LVMI and other cardiac structure indexes were significantly lower in observation group than in control group (P <0.05);No serious adverse reactions took place in this study.Conclusion Alprostadil injection can effectively and safely protect the myocardial function in patients with severe organic phosphorus pesticide poisoning and is worth to be popularized.