2013年河北省细菌耐药监测网三级甲等医院临床分离铜绿假单胞菌耐药性监测
2013년하북성세균내약감측망삼급갑등의원림상분리동록가단포균내약성감측
Surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates from third-grade class A hospitals of Hebei Antibacterial Resistance Investigation Net in 2013
  • 万方数据
    临床荟萃 림상회췌
    CLINICAL FOCUS
    2015年 9期 974-977 ,共4页

    董爱英%时东彦%曹丽军%孙艳%王迁%崔幸坤%谢守军%冯军%赵文申%陈玉兰%李洪臣%郭映辉%冯忠军%张金艳%张征%李士英%安翠萍%李书君%王雁勇%李志荣%赵建宏

    동애영%시동언%조려군%손염%왕천%최행곤%사수군%풍군%조문신%진옥란%리홍신%곽영휘%풍충군%장금염%장정%리사영%안취평%리서군%왕안용%리지영%조건굉

    铜绿假单胞菌%耐药监测%病原菌 銅綠假單胞菌%耐藥鑑測%病原菌
    동록가단포균%내약감측%병원균
    pseudomonas aeruginosa%resistance monitoring%hebei province
    目的：监测2013年河北省细菌耐药性监测网(hebei Antibacterial Resistance Investigation Net,Hebarin)三级甲等成员单位临床分离铜绿假单胞菌的病原菌特点,为指导临床针对铜绿假单胞菌感染的合理用药提供依据。方法对河北省细菌耐药监测网2013年度18家三级甲等医院分离菌株,采用纸片法、最低抑菌浓度(MIC)法或 E-test 法测定其药物敏感性,并以 WHONET 5.5软件进行数据统计分析。结果2013年河北省地区各类标本共分离出铜绿假单胞菌5190株,排名前3位的分别是：呼吸道标本分离3581株(69.5%),尿标本分离557株(10.8%),分泌物中分离314株(6.1%)；耐药性分析中,铜绿假单胞菌对多粘菌素和阿米卡星耐药率较低外,对其他抗菌药物耐药率均>20%,其中美罗培南的耐药率为38.6%,其次为氨曲南、哌拉西林、庆大霉素、亚胺培南,耐药率分别是37.1%、35.0%、33.5%、33.3%。结论我省临床分离的铜绿假单胞菌对常用抗菌药物的耐药性任处于较高水平,应继续加强细菌耐药监测。
    목적：감측2013년하북성세균내약성감측망(hebei Antibacterial Resistance Investigation Net,Hebarin)삼급갑등성원단위림상분리동록가단포균적병원균특점,위지도림상침대동록가단포균감염적합리용약제공의거。방법대하북성세균내약감측망2013년도18가삼급갑등의원분리균주,채용지편법、최저억균농도(MIC)법혹 E-test 법측정기약물민감성,병이 WHONET 5.5연건진행수거통계분석。결과2013년하북성지구각류표본공분리출동록가단포균5190주,배명전3위적분별시：호흡도표본분리3581주(69.5%),뇨표본분리557주(10.8%),분비물중분리314주(6.1%)；내약성분석중,동록가단포균대다점균소화아미잡성내약솔교저외,대기타항균약물내약솔균>20%,기중미라배남적내약솔위38.6%,기차위안곡남、고랍서림、경대매소、아알배남,내약솔분별시37.1%、35.0%、33.5%、33.3%。결론아성림상분리적동록가단포균대상용항균약물적내약성임처우교고수평,응계속가강세균내약감측。
    Objective To analyze the clinical isolated pathogen characteristics of Pseudomonas aeruginosa from the National Antimicrobial Resistance Investigation Net in Hebei Province in 2013,and to provide the basis for the rational use of drugs in clinical infection of Pseudomonas aeruginosa.Methods Bacterial drug sensitivity was detected by disk method,MIC method or E-test method and data were statistically analyzed using WHONET 5.5 software. Results There were 5 1 90 strains of Pseudomonas aeruginosa isolated from all kinds of clinical specimens in Hebei Province in 2013.The top three were respiratory tract specimens (3 581 strains,69.5% ),urine specimens (557 strains,10.8% ), secretion specimens (314 strains, 6.1% ). Drug-resistance experiment showed that the drug resistance rate of Pseudomonas aeruginosa to polymyxin B and amikacin was lower,the others were more than 20%, including the highest resistance rate of Pseudomonas aeruginosa to meropenem (38.6% ),aztreonam (37.1% ), piperacillin (35.0%),gentamycin (33.5%),and impenem (33.3%).Conclusion Pseudomonas aeruginosa isolated from clinic is still at a high level of resistance to commonly used antimicrobial agents in Hebei Province.Surveillance of bacterial resistance should be strengthened.
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