CAJ | 학술논문

目的：通过评价125 I粒子植入术对于眼外期视网膜母细胞瘤（ RB）的治疗效果及副作用，旨在为眼外期RB临床治疗探索新的途径。方法对7例（7只眼）（男性2例，女性5例）眼外期RB患儿，平均年龄（20．4±7.2）个月，将肿瘤残存视神经作为靶区，采用125 I粒子组织间植入术结合CT印证，观察其治疗效果并进行副作用分析。结果7例眼外期RB患儿眼眶残留视神经周围行125 I放射性粒子组织间植入，随访至2015年3月，随访11～96个月，中位随访时间为47个月，病情达到完全缓解5例，死亡2例，总生存率为71．3％（5／7）。2年生存率80％，5年预计存活率40％，7例均无局部副作用。结论125 I放射性粒子植入术可以使眼外期RB患儿减少颅内播散，提高生存率，且毒副作用小，为眼外期RB患儿提供一新的安全可行的治疗方法。
목적：통과평개125 I입자식입술대우안외기시망막모세포류（ RB）적치료효과급부작용，지재위안외기RB림상치료탐색신적도경。방법대7례（7지안）（남성2례，녀성5례）안외기RB환인，평균년령（20．4±7.2）개월，장종류잔존시신경작위파구，채용125 I입자조직간식입술결합CT인증，관찰기치료효과병진행부작용분석。결과7례안외기RB환인안광잔류시신경주위행125 I방사성입자조직간식입，수방지2015년3월，수방11～96개월，중위수방시간위47개월，병정체도완전완해5례，사망2례，총생존솔위71．3％（5／7）。2년생존솔80％，5년예계존활솔40％，7례균무국부부작용。결론125 I방사성입자식입술가이사안외기RB환인감소로내파산，제고생존솔，차독부작용소，위안외기RB환인제공일신적안전가행적치료방법。
Objective To study the efficacy and safety of 125 I particles implants in the treatment of children’ s pa-tients with extraocular retinoblastoma( RB) .Methods 7 cases (male 2,female 5)of extraocular RB received the 125I particles implants targeted to the optic nerve by tumor involvement associated with CT examination and analysis the treat-ment outcome and side-effect.Results 7 case follow up for 11~96 months,median follow up time is 47months.5 cases achieved a complete remission, total survival rate is 71.3%(5/7).Nobody had radiotherapy side effect after the operations .Conclusion Radioactive 125 I seeds interstitial brachytherapy was an effective treatment for children with extraocular RB .