医学分子生物学杂志
醫學分子生物學雜誌
의학분자생물학잡지
FOREIGN MEDICAL SCIENCES
2015年
4期
238-242
,共5页
青光眼%视网膜神经节细胞%胶质细胞%TNF-α
青光眼%視網膜神經節細胞%膠質細胞%TNF-α
청광안%시망막신경절세포%효질세포%TNF-α
glaucoma%retinal gaglion cells%Glia cells%tumor necrosis factor-alpha
肿瘤坏死因子?α（ tumor necrosis factor?alpha， TNF?α）是一种多源性、多效性的细胞因子，参与多种病理生理活动。近年来多项研究表明TNF?α参与青光眼发病及进展。青光眼中视网膜胶质细胞被激活后，其产生细胞毒素如TNF?α， TNF?α与肿瘤坏死因子受体1（tumor necrosis factor receptor 1， TNFR1）的表达增加，从而引起视网膜神经节细胞（ retinal gaglion cells， RGCs）凋亡，最终导致视神经病变。另外， TNF?α也可诱导其他细胞毒性物质产生，进而加重青光眼视神经损伤。
腫瘤壞死因子?α（ tumor necrosis factor?alpha， TNF?α）是一種多源性、多效性的細胞因子，參與多種病理生理活動。近年來多項研究錶明TNF?α參與青光眼髮病及進展。青光眼中視網膜膠質細胞被激活後，其產生細胞毒素如TNF?α， TNF?α與腫瘤壞死因子受體1（tumor necrosis factor receptor 1， TNFR1）的錶達增加，從而引起視網膜神經節細胞（ retinal gaglion cells， RGCs）凋亡，最終導緻視神經病變。另外， TNF?α也可誘導其他細胞毒性物質產生，進而加重青光眼視神經損傷。
종류배사인자?α（ tumor necrosis factor?alpha， TNF?α）시일충다원성、다효성적세포인자，삼여다충병리생리활동。근년래다항연구표명TNF?α삼여청광안발병급진전。청광안중시망막효질세포피격활후，기산생세포독소여TNF?α， TNF?α여종류배사인자수체1（tumor necrosis factor receptor 1， TNFR1）적표체증가，종이인기시망막신경절세포（ retinal gaglion cells， RGCs）조망，최종도치시신경병변。령외， TNF?α야가유도기타세포독성물질산생，진이가중청광안시신경손상。
Tumor necrosis factor?alpha ( tumor necrosis factor?alpha, TNF?ɑ) is a multifocal and pleiotropic cytokine that is involved in a wide range of pathological and physiological functions?Recently, growing evidence has suggested the role of TNF?ɑin the occurrence and devel?opment of glaucoma?The risk factors of glaucoma activate retinal glial cells which produce cytotoxins like TNF?α?Increased expression of TNF?αand its receptor TNF?R1 causes retinal gaglion cells ( ret?inal gaglion cells, RGCs ) apoptosis, which leads to glaucomatous neurodegeneration?Besides, TNF?αalso induces production of other cytotoxic substances which aggravate the nerve damage ?In this article, we discuss several aspects like the mechanisms of deleterious role of TNF?ɑin glaucoma optic nerve.
