CAJ | 학술논문

紫杉醇是一种二萜类生物碱，通过抑制微管解聚和稳定微管的作用来抑制有丝分裂，是一种高效、低毒、广谱的天然抗癌药物，已在临床上广泛使用，市场需求量巨大，但由于生产原料的制约，价格十分昂贵。近年来的研究表明，利用植物内生真菌发酵生产紫杉醇是解决药源问题的有效途径。本文就产紫杉醇内生真菌的分离与鉴定方法、紫杉醇的提取与检测技术及在研的菌种进行综述，并进一步提出目前内生真菌源紫杉醇研究存在的问题与前景。
자삼순시일충이첩류생물감，통과억제미관해취화은정미관적작용래억제유사분렬，시일충고효、저독、엄보적천연항암약물，이재림상상엄범사용，시장수구량거대，단유우생산원료적제약，개격십분앙귀。근년래적연구표명，이용식물내생진균발효생산자삼순시해결약원문제적유효도경。본문취산자삼순내생진균적분리여감정방법、자삼순적제취여검측기술급재연적균충진행종술，병진일보제출목전내생진균원자삼순연구존재적문제여전경。
Taxol was a chemical substance of diterpene alkaloid with high efficiency, low toxicity and broad-spectrum, which could inhibit mitosis through enhancement of polymerization of tubulin and con-sequent stabilization of microtubules during the process of cell division. It had become a widely used drug in clinic. The industrial fermentation of taxol by fungi had been promised an effective way to increase the production and supply of the drug in the market. The isolation and identification of endophytic fungi types, extraction and detection methods, the strains in the research and some problems and prospect of taxol from endophytic fungi were summarized.