国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2015年
4期
179-183
,共5页
结直肠癌%长链非编码RNA%肿瘤易感候选基因11
結直腸癌%長鏈非編碼RNA%腫瘤易感候選基因11
결직장암%장련비편마RNA%종류역감후선기인11
Colorectal cancer%Long non-coding RNA%Cancer susceptibility candidate 11
目的 本研究对人结直肠癌中长链非编码RNA-CASC11的表达情况进行检测,同时分析其表达水平与临床病理因素之间的关系,探讨CASC11在结直肠癌诊断、预后分析等方面的临床意义和价值.方法 运用qRT-PCR检测76对结直肠癌及癌旁正常组织中CASC11的表达水平.通过Logistic回归和Log-Rank方法分别分析其表达水平与临床病理因素和预后的关系.结果 发现CASC11在结直肠癌组织中存在明显的表达下调(P=0.001),并且与肿瘤转移存在负相关(P=0.037,OR=0.321).同时CASC11的低表达患者表现出更差的预后(P=0.017).结论 结直肠癌中CASC11的表达下调预示不良预后.
目的 本研究對人結直腸癌中長鏈非編碼RNA-CASC11的錶達情況進行檢測,同時分析其錶達水平與臨床病理因素之間的關繫,探討CASC11在結直腸癌診斷、預後分析等方麵的臨床意義和價值.方法 運用qRT-PCR檢測76對結直腸癌及癌徬正常組織中CASC11的錶達水平.通過Logistic迴歸和Log-Rank方法分彆分析其錶達水平與臨床病理因素和預後的關繫.結果 髮現CASC11在結直腸癌組織中存在明顯的錶達下調(P=0.001),併且與腫瘤轉移存在負相關(P=0.037,OR=0.321).同時CASC11的低錶達患者錶現齣更差的預後(P=0.017).結論 結直腸癌中CASC11的錶達下調預示不良預後.
목적 본연구대인결직장암중장련비편마RNA-CASC11적표체정황진행검측,동시분석기표체수평여림상병리인소지간적관계,탐토CASC11재결직장암진단、예후분석등방면적림상의의화개치.방법 운용qRT-PCR검측76대결직장암급암방정상조직중CASC11적표체수평.통과Logistic회귀화Log-Rank방법분별분석기표체수평여림상병리인소화예후적관계.결과 발현CASC11재결직장암조직중존재명현적표체하조(P=0.001),병차여종류전이존재부상관(P=0.037,OR=0.321).동시CASC11적저표체환자표현출경차적예후(P=0.017).결론 결직장암중CASC11적표체하조예시불량예후.
Objective The aim of this study was to evaluate the expression of long non-coding RNA (lncRNA) CASC11 in colorectal cancer (CRC) tissues,and to determine its correlation with clinicopathological characteristics and its impact on patient prognosis.Methods The expression of CASC11 was detected by qRT-PCR in 76 pairs of CRC tissues.Relationship between the expression level of CASC11 and various clinicopathological features and prognosis of CRC were analyzed by logistic regress and log-rank,respectively.Results Our results showed that CASC11 was down-regulated in colorectal cancer (P =0.001),and the expression of CASC11 was strongly associated with metastasis (P =0.037,OR=0.321).Patients with CASC11 down-regulation had lower overall survival rate than those with high CASC11 expression (P =0.017).Conclusion The down-regulation of CASC11 may represent a novel and potentially independent biomarker for the prognosis of CRC patients.
