CAJ | 학술논문

目的：探讨甲巯咪唑（MM）治疗初发甲状腺功能亢进（简称甲亢）致白细胞减少症的临床风险因素。方法收集100例给予 MM治疗的初发甲亢患者的临床资料，对可能影响外周血白细胞减少的因素进行非条件 Logistic 回归分析。结果白细胞减少组与白细胞正常组性别比例、老年比例、过敏史、促甲状腺素受体抗体（TRAb）水平比较，差异无统计学意义（P ＜0．05），Logistic 多元回归分析结果显示，体质量指数（BMI）、MM起始剂量对回归方程有统计学意义（P ＜0．05）。结论BMI、MM起始剂量是 MM治疗初发甲亢最初3个月内发生白细胞减少症的危险因素。
목적：탐토갑구미서（MM）치료초발갑상선공능항진（간칭갑항）치백세포감소증적림상풍험인소。방법수집100례급여 MM치료적초발갑항환자적림상자료，대가능영향외주혈백세포감소적인소진행비조건 Logistic 회귀분석。결과백세포감소조여백세포정상조성별비례、노년비례、과민사、촉갑상선소수체항체（TRAb）수평비교，차이무통계학의의（P ＜0．05），Logistic 다원회귀분석결과현시，체질량지수（BMI）、MM기시제량대회귀방정유통계학의의（P ＜0．05）。결론BMI、MM기시제량시 MM치료초발갑항최초3개월내발생백세포감소증적위험인소。
Objective To explore the risk factors of leukopenia caused by methimazole treatment of primary hyperthyroidism.Methods 100 patients with hyperthyroidism in methimazole treatment were selected,affecting factors of leukopenia were analysed by means of multiple factors unconditional Logistic regression.Results Between patients with leukopenia and without leukopenia,there were no significant difference in sex ratio,the elderly proportion,drug allergy history and level of human thyroid stimulating hormone receptor antidoby(TRAb)(P <0.05),multiple Logistic regression analysis results showed that body mass index (BMI)and the initial dose of methimazole had significant impact on the regression equation(P <0.05 ).Conclusion BMI and the initial dose of methimazole are the risk factors of leukopenia occurrence in methimazole treatment during the first three months.