临床与病理杂志
臨床與病理雜誌
림상여병리잡지
International Journal of Pathology and Clinical Medicine
2015年
z1期
20-24
,共5页
苏永辉%侯冰宗%徐家琪%卜巨源%李宵凌
囌永輝%侯冰宗%徐傢琪%蔔巨源%李宵凌
소영휘%후빙종%서가기%복거원%리소릉
SUZ12%结直肠癌%免疫组织化学
SUZ12%結直腸癌%免疫組織化學
SUZ12%결직장암%면역조직화학
SUZ12%colorectal cancer%immunohistochemistry
目的:探讨PRC2成分SUZ12在结直肠癌组织中的表达及其与临床病理特征的关系。方法:应用免疫组织化学技术检测检测2012年6月至2013年6月我院76例结直肠癌患者手术切除的肿瘤组织和配对癌旁正常组织中SUZ12的表达,分析SUZ12与结直肠癌临床病理特征的相关性。结果:SUZ12在结直肠癌组织表达水平(9.24±4.47)明显高于配对的正常结直肠组织(3.45±2.78),两者差异有统计学意义(P<0.01),SUZ12表达水平与结直肠癌组织学分化程度(P=0.014)、TNM分期(P=0.016)及淋巴结转移(P=0.036)有关,而与患者的年龄、性别、肿瘤的部位、大小及浸润深度无明显相关(P>0.05)。结论:SUZ12表达与结直肠癌侵袭和转移密切相关,可以作为评估结直肠癌恶性程度新的指标。
目的:探討PRC2成分SUZ12在結直腸癌組織中的錶達及其與臨床病理特徵的關繫。方法:應用免疫組織化學技術檢測檢測2012年6月至2013年6月我院76例結直腸癌患者手術切除的腫瘤組織和配對癌徬正常組織中SUZ12的錶達,分析SUZ12與結直腸癌臨床病理特徵的相關性。結果:SUZ12在結直腸癌組織錶達水平(9.24±4.47)明顯高于配對的正常結直腸組織(3.45±2.78),兩者差異有統計學意義(P<0.01),SUZ12錶達水平與結直腸癌組織學分化程度(P=0.014)、TNM分期(P=0.016)及淋巴結轉移(P=0.036)有關,而與患者的年齡、性彆、腫瘤的部位、大小及浸潤深度無明顯相關(P>0.05)。結論:SUZ12錶達與結直腸癌侵襲和轉移密切相關,可以作為評估結直腸癌噁性程度新的指標。
목적:탐토PRC2성분SUZ12재결직장암조직중적표체급기여림상병리특정적관계。방법:응용면역조직화학기술검측검측2012년6월지2013년6월아원76례결직장암환자수술절제적종류조직화배대암방정상조직중SUZ12적표체,분석SUZ12여결직장암림상병리특정적상관성。결과:SUZ12재결직장암조직표체수평(9.24±4.47)명현고우배대적정상결직장조직(3.45±2.78),량자차이유통계학의의(P<0.01),SUZ12표체수평여결직장암조직학분화정도(P=0.014)、TNM분기(P=0.016)급림파결전이(P=0.036)유관,이여환자적년령、성별、종류적부위、대소급침윤심도무명현상관(P>0.05)。결론:SUZ12표체여결직장암침습화전이밀절상관,가이작위평고결직장암악성정도신적지표。
Objective:To investigate the role of polycomb-repressive complex 2 component SUZ12 in colorectal cancer. Methods: Expression of SUZ12 was studied in archived specimens from 76 colorectal cancer patients by immunohistochemistry. Relationships between SUZ12 expression and clinicopathological characters were analyzed.Results:Expression of SUZ12 protein in colorectal cancer tissues was significantly higher than that in paratumor tissues (9.24±4.47 vs. 3.45±2.78,P<0.01). SUZ12 expression was significantly correlated with tumor differentiation (P=0.014), TNM stage (P=0.016) and lymph nodes metastasis (P=0.036), but not with the patients age, gender, tumor location, tumor size or tumor invasion(P>0.05).Conclusion: Over expression of SUZ12 is associated with more aggressive colorectal cancer and might be a biomarker for metastatic colorectal cancer.