CAJ | 학술논문

目的：拟通过荟萃分析确定血清重组烟曲霉抗原4特异性 IgE（rASP f 4-sIgE）对变应性支气管肺曲菌病（ABPA）的诊断价值。方法收集相关文献，提取资料进行系统评价，用随机效应模型汇总各研究中 rASP f 4-sIgE 诊断 ABPA 的准确性指标，绘制汇总受试者工作特征曲线并探讨其诊断特性。结果按照纳入标准有10项研究最终入选。rASP f 4-sIgE 诊断 ABPA 的合并敏感度为0．824；特异度为0．966；阳性似然比为14．682；阴性似然比为0．206；诊断优势比为105．200。结论rASP f 4-sIgE 诊断 ABPA 的敏感度和特异度均高，测量血清中 rASP f 4-sIgE 有助于诊断ABPA。分析 rASP f 4-sIgE 结果需与其它临床表现及常规检验结果相结合。
목적：의통과회췌분석학정혈청중조연곡매항원4특이성 IgE（rASP f 4-sIgE）대변응성지기관폐곡균병（ABPA）적진단개치。방법수집상관문헌，제취자료진행계통평개，용수궤효응모형회총각연구중 rASP f 4-sIgE 진단 ABPA 적준학성지표，회제회총수시자공작특정곡선병탐토기진단특성。결과안조납입표준유10항연구최종입선。rASP f 4-sIgE 진단 ABPA 적합병민감도위0．824；특이도위0．966；양성사연비위14．682；음성사연비위0．206；진단우세비위105．200。결론rASP f 4-sIgE 진단 ABPA 적민감도화특이도균고，측량혈청중 rASP f 4-sIgE 유조우진단ABPA。분석 rASP f 4-sIgE 결과수여기타림상표현급상규검험결과상결합。
Objective To perform a meta-analysis to determine the accuracy of recombinant Aspergillus fumigatus allergen 4 specific immunoglobulin E(rASP f 4-sIgE)measurement in the diagnosis of allergic bronchopulmonary aspergillosis(ABPA).Methods A systematic review of associated studies was conducted and data on the accuracy of rASP f 4-sIgE in sera for the diagnosis of ABPA were pooled using random effects models.Summary receiver operating characteristic curve was used to summarize overall test performance.Results Ten studies met our inclusion criteria.The summary estimation for rASP f 4-sIgE in the diagnosis of ABPA in the studies included were:sensitivity 0.824,specificity 0.966, positive likelihood ratio 14.682,negative likelihood ratio 0.206 and diagnostic odds ratio 105.200. Conclusion rASP f 4-sIgE determination is a sensitive and specific test for the diagnosis of ABPA. Measurement of rASP f 4-sIgE in sera is thus likely to be a useful diagnostic tool for ABPA.The results of rASP f 4-sIgE assays should be interpreted in parallel with clinical findings and the results of conventional tests.