CAJ | 학술논문

目的：观察支气管哮喘-慢性阻塞性肺疾病重叠综合征（ACOS）患者血清维生素 D 的水平情况，探讨维生素 D 不足或缺乏对 ACOS 患者的影响。方法收集 ACOS 患者和同期体检健康对照者各48例，采用酶联免疫吸附试验（ELISA）法测定其血清中的25-羟维生素 D[25-（OH）D]水平；将 ACOS 患者的急性发作频率、第1秒用力呼气容积占预计值百分比（FEV1％）和25-（OH）D水平作相关分析。结果ACOS 患者的血清中25-（OH）D 水平[（32．26±9．97）nmol／L]明显低于对照组[（51．00±14．61）nmol／L，P ＜0．05]。ACOS 患者的25-（OH）D 水平与其急性发作次数呈负相关（r ＝－0．70，P ＜0．05），与患者 FEV1％呈正相关（r ＝0．68，P ＜0．05）。结论维生素 D 不足或缺乏在 ACOS 患者中患病率较高，且与 ACOS 患者的急性发作次数和 FEV1％相关。
목적：관찰지기관효천-만성조새성폐질병중첩종합정（ACOS）환자혈청유생소 D 적수평정황，탐토유생소 D 불족혹결핍대 ACOS 환자적영향。방법수집 ACOS 환자화동기체검건강대조자각48례，채용매련면역흡부시험（ELISA）법측정기혈청중적25-간유생소 D[25-（OH）D]수평；장 ACOS 환자적급성발작빈솔、제1초용력호기용적점예계치백분비（FEV1％）화25-（OH）D수평작상관분석。결과ACOS 환자적혈청중25-（OH）D 수평[（32．26±9．97）nmol／L]명현저우대조조[（51．00±14．61）nmol／L，P ＜0．05]。ACOS 환자적25-（OH）D 수평여기급성발작차수정부상관（r ＝－0．70，P ＜0．05），여환자 FEV1％정정상관（r ＝0．68，P ＜0．05）。결론유생소 D 불족혹결핍재 ACOS 환자중환병솔교고，차여 ACOS 환자적급성발작차수화 FEV1％상관。
Objective To observe the serum levels of vitamin D in patients with asthma-chronic obstructive pulmonary disease overlap syndrome(ACOS),and to explore the effect of vitamin Ddeficiency or lack on the ACOS patients.Methods Forty-eight ACOS patients and forty-eight healthy subjects were enrolled in our study.The serum levels of 25-(OH)D were measured by enzyme-linked immunosorbent assay (ELISA).The correlation analysis were used for the incidence of exacerbations,forced expiratory volume in one second to forced vital capacity ratio(FEV1 %)and the levels of 25-(OH)D in the ACOS patients. Results The levels of 25-(OH)D were significantly lower in the ACOS patients[(32.26 ±9.97)nmol/L] than those in the healthy subjects[(51.00 ±14.61)nmol/L,P <0.05].25-(OH)D level was negatively correlated with the incidence of exacerbations(r =-0.70,P <0.05),and positively correlated with FEV1 %(r =0.68,P <0.05 ).Conclusion Vitamin D deficiency or lack is highly prevalent in the ACOS patients,which may be correlated with the increased incidence of exacerbations and the declined level of FEV1 % in the ACOS patients.