济宁医学院学报
濟寧醫學院學報
제저의학원학보
JOURNAL OF JINING MEDICAL COLLEGE
2015年
4期
247-250
,共4页
张波%王启平%王慧云%全先高%王盈盈%王宁
張波%王啟平%王慧雲%全先高%王盈盈%王寧
장파%왕계평%왕혜운%전선고%왕영영%왕저
甲氨蝶呤%囊泡%包封率%正交实验
甲氨蝶呤%囊泡%包封率%正交實驗
갑안접령%낭포%포봉솔%정교실험
Methotrexate%Niosomes%Entrapment efficiency%Orthogonal test
目的:制备甲氨蝶呤囊泡并通过正交实验优化甲氨蝶呤囊泡的制备工艺,探索最适宜的药物包封条件。方法采用L9(34)正交法优化甲氨蝶呤囊泡对药物包封率的影响因素,以囊泡包封率为考察指标,确定最佳制备工艺条件。结果司盘40(Span40)与胆固醇形成的囊泡(VSpan40∶VCHOL =4∶2),在50℃超声40 min 的条件下,对0.60 g/L 的甲氨蝶呤包封率最高,可达60%以上。结论通过正交实验优化制得的甲氨蝶呤囊泡可获得较高的包封率。
目的:製備甲氨蝶呤囊泡併通過正交實驗優化甲氨蝶呤囊泡的製備工藝,探索最適宜的藥物包封條件。方法採用L9(34)正交法優化甲氨蝶呤囊泡對藥物包封率的影響因素,以囊泡包封率為攷察指標,確定最佳製備工藝條件。結果司盤40(Span40)與膽固醇形成的囊泡(VSpan40∶VCHOL =4∶2),在50℃超聲40 min 的條件下,對0.60 g/L 的甲氨蝶呤包封率最高,可達60%以上。結論通過正交實驗優化製得的甲氨蝶呤囊泡可穫得較高的包封率。
목적:제비갑안접령낭포병통과정교실험우화갑안접령낭포적제비공예,탐색최괄의적약물포봉조건。방법채용L9(34)정교법우화갑안접령낭포대약물포봉솔적영향인소,이낭포포봉솔위고찰지표,학정최가제비공예조건。결과사반40(Span40)여담고순형성적낭포(VSpan40∶VCHOL =4∶2),재50℃초성40 min 적조건하,대0.60 g/L 적갑안접령포봉솔최고,가체60%이상。결론통과정교실험우화제득적갑안접령낭포가획득교고적포봉솔。
Objective The preparation process of the methotrexate niosomes were optimized by means of orthog-onal experiment to explore the most suitable drug coating conditions.Methods The methotrexate encapsulation rate affecting factors was optimized by an L9 (3 4 )orthogonal test.The niosomes encapsulation rate as evaluation index was used to determine the best preparation program.Results The results showed that the entrapment efficiency of the niosomes prepared under the condition which were as follows:Span40 and cholesterol (VSpan40∶VCHOL)was 2∶1,the dosage of methotrexate,Ultrasonic temperature and time were 0.60g/L,50℃ and 40min,and the entrap-ment rate could reach more than 60%.Conclusion The methotrexate niosomes optimized by orthogonal test had a higher entrapment rate.