CAJ | 학술논문

人类内源性逆转录病毒（human endogenous retrovirus，HERV）是外源型逆转录病毒侵入并整合人类基因组中的残余物。HERV 及长末端段重复序列（LTR）约占了整个基因组的8％。HERV 的遗传不稳定性使 HERV 在基因组中分布广泛，HERV LTR 的结构特性可以诱发产生新的基因、调节病毒的编码基因与相邻宿主基因的异常表达。而病毒基因的功能及相邻的肿瘤基因的异常表达是肿瘤发生的重要因素。本文从HERV 的起源、结构、分布出发探讨 HERV 参与肿瘤病理发生的现状及分子机制。
인류내원성역전록병독（human endogenous retrovirus，HERV）시외원형역전록병독침입병정합인류기인조중적잔여물。HERV 급장말단단중복서렬（LTR）약점료정개기인조적8％。HERV 적유전불은정성사 HERV 재기인조중분포엄범，HERV LTR 적결구특성가이유발산생신적기인、조절병독적편마기인여상린숙주기인적이상표체。이병독기인적공능급상린적종류기인적이상표체시종류발생적중요인소。본문종HERV 적기원、결구、분포출발탐토 HERV 삼여종류병리발생적현상급분자궤제。
Human endogenous retrovirus (HERV)is known as the residue of exogenous retrovirus during the integration in the human genome.HERV and long terminal repeat constitute 8% of the human genome.HERV is widely distributed in the human genome owing to its genetic instability.The feature of HERV LTR can induce the initial transcription of new genes and regulate the expression of viral gene and adjacent host gene.Overexpression of viral protein and LTR-associated oncogene are vital factors for tumorigenesis.In this review,we examined the origin,structure,distribution of HERV to investigate the molecular mechanism of HERV in tumor pathology process.