CAJ | 학술논문

目的:探讨P53上调凋亡因子(P53 up-regulated modulator of apoptosis PUMA)在喉鳞癌中的表达及其与临床的关系.方法:采用免疫组织化学法检测35例喉鳞状细胞癌正常组织中PUMA的表达情况,并结合临床,分析其与临床病理特征及预后的关系.结果:PUMA蛋白在喉鳞癌中的表达明显低于正常组织,二者之间的比较差异有统计学意义(P<0.05);在喉鳞癌中PUMA与不同临床分期、病理组织学分级、淋巴结转移情况有相关性.结论:PUMA在喉鳞癌组织中呈低表达,PUMA阳性表达组的喉鳞癌患者中,生存率及生存时间明显高于阴性表达者.
목적:탐토P53상조조망인자(P53 up-regulated modulator of apoptosis PUMA)재후린암중적표체급기여림상적관계.방법:채용면역조직화학법검측35례후린상세포암정상조직중PUMA적표체정황,병결합림상,분석기여림상병리특정급예후적관계.결과:PUMA단백재후린암중적표체명현저우정상조직,이자지간적비교차이유통계학의의(P<0.05);재후린암중PUMA여불동림상분기、병리조직학분급、림파결전이정황유상관성.결론:PUMA재후린암조직중정저표체,PUMA양성표체조적후린암환자중,생존솔급생존시간명현고우음성표체자.
Objective:To investigate the regulation of apoptosis factor P53 (P53 up-regulated modulator of apoptosis PUMA) and its relationship with the clinical expression in laryngeal squamous cell.Method: The expression of 35 cases of laryngeal squamous cell carcinoma PUMA normal tissues using immunohistochemical method, and clinical analysis of its relationship with clinicopathological features and prognosis.Result:The expression of PUMA protein in laryngeal squamous cell carcinoma was significantly lower than in normal tissue, were more significant between the two,(P<0.05); in laryngeal squamous cell PUMA with different clinical stages, histological grade, lymph node metastasis correlated.Conclusion:PUMA in laryngeal squamous cell carcinoma was low expression PUMA laryngeal squamous cell carcinoma positive expression group, the survival rate and survival time was significantly higher than the negative expression.