中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
CHINESE JOURNAL OF EMERGENCY MEDICINE
2015年
8期
882-886
,共5页
田朝伟%王丽%晋荣%钟赟%刘世明
田朝偉%王麗%晉榮%鐘赟%劉世明
전조위%왕려%진영%종빈%류세명
代谢综合征%糖尿病%可溶性晚期糖基化终产物受体%脉搏波传导速度%动脉僵硬度%动脉粥样硬化,高密度脂蛋白胆固醇%胰岛素抵抗
代謝綜閤徵%糖尿病%可溶性晚期糖基化終產物受體%脈搏波傳導速度%動脈僵硬度%動脈粥樣硬化,高密度脂蛋白膽固醇%胰島素牴抗
대사종합정%당뇨병%가용성만기당기화종산물수체%맥박파전도속도%동맥강경도%동맥죽양경화,고밀도지단백담고순%이도소저항
Metabolic syndrome%Diabetes mellitus%Soluble receptor for advanced glycation endproducts%Pulse wave velocity%Arterial stiffness%Atherosclerosis%High density lipoprotein cholesterol%Insulin resistance
目的 探讨在不同类型代谢综合征(metabolic syndrome,MS)患者血浆中可溶性晚期糖基化终产物受体(soluble receptor for advanced glycation endproducts,sRAGE)与动脉僵硬度的关系.方法 采用病例对照的方法,选择非代谢综合征(non metabolic syndrome,NMS)患者60例,非糖尿病代谢综合征(metabolic syndrome without diabetes mellitus,NDMMS)患者60例,糖尿病代谢综合征(metabolic syndrome with diabetes mellitus,DMMS)患者60例,对所有研究对象行相关血液生化检查,ELISA法检测研究对象血浆中sRAGE水平,用法国康普乐动脉硬化测量仪检测颈股动脉脉搏波传导速(carotid-femoral pulse wave velocity,CFPWV).多组间均数比较采用方差分析,组间两两比较使用LSD-t检验;sRAGE与CFPWV的相关性分析采用Pearson相关分析,采用Stepwise法进行多重线性回归对影响CFPWV的因素进行分析;以P＜0.05为差异有统计学意义.结果 DMMS组和NDMMS组的sRAGE水平明显低于NMS组[(635.07±229.20)pg/ml vs.(671.17±358.16) pg/ml vs.(992.99 ±427.83) pg/ml,P=0.001];DMMS组的CFPWV明显高于NDMMS组与NMS组[(14.22±3.14) m/s vs.(12.15±2.79) m/svs.(11.66±2.52) m/s,P =0.002].sRAGE与CFPWV呈负相关(r:-0.278,P=0.005).多重线性回归分析显示年龄(β=-0.091,95％ CI-0.096 ～-0.095,P=0.031)是CFPWV的危险因素,而HDL-C(β=1.295,95％ CI1.231 ～1.360,P=0.022)和sRAGE (β=0.119,95％ CI 0.118～0.130,P=0.032)是CFPWV的保护因素.结论 随着血浆中sRAGE水平下降MS患者大动脉僵硬度增加,血浆中sRAGE水平升高可能对早期血管病变具有保护作用.
目的 探討在不同類型代謝綜閤徵(metabolic syndrome,MS)患者血漿中可溶性晚期糖基化終產物受體(soluble receptor for advanced glycation endproducts,sRAGE)與動脈僵硬度的關繫.方法 採用病例對照的方法,選擇非代謝綜閤徵(non metabolic syndrome,NMS)患者60例,非糖尿病代謝綜閤徵(metabolic syndrome without diabetes mellitus,NDMMS)患者60例,糖尿病代謝綜閤徵(metabolic syndrome with diabetes mellitus,DMMS)患者60例,對所有研究對象行相關血液生化檢查,ELISA法檢測研究對象血漿中sRAGE水平,用法國康普樂動脈硬化測量儀檢測頸股動脈脈搏波傳導速(carotid-femoral pulse wave velocity,CFPWV).多組間均數比較採用方差分析,組間兩兩比較使用LSD-t檢驗;sRAGE與CFPWV的相關性分析採用Pearson相關分析,採用Stepwise法進行多重線性迴歸對影響CFPWV的因素進行分析;以P＜0.05為差異有統計學意義.結果 DMMS組和NDMMS組的sRAGE水平明顯低于NMS組[(635.07±229.20)pg/ml vs.(671.17±358.16) pg/ml vs.(992.99 ±427.83) pg/ml,P=0.001];DMMS組的CFPWV明顯高于NDMMS組與NMS組[(14.22±3.14) m/s vs.(12.15±2.79) m/svs.(11.66±2.52) m/s,P =0.002].sRAGE與CFPWV呈負相關(r:-0.278,P=0.005).多重線性迴歸分析顯示年齡(β=-0.091,95％ CI-0.096 ～-0.095,P=0.031)是CFPWV的危險因素,而HDL-C(β=1.295,95％ CI1.231 ～1.360,P=0.022)和sRAGE (β=0.119,95％ CI 0.118～0.130,P=0.032)是CFPWV的保護因素.結論 隨著血漿中sRAGE水平下降MS患者大動脈僵硬度增加,血漿中sRAGE水平升高可能對早期血管病變具有保護作用.
목적 탐토재불동류형대사종합정(metabolic syndrome,MS)환자혈장중가용성만기당기화종산물수체(soluble receptor for advanced glycation endproducts,sRAGE)여동맥강경도적관계.방법 채용병례대조적방법,선택비대사종합정(non metabolic syndrome,NMS)환자60례,비당뇨병대사종합정(metabolic syndrome without diabetes mellitus,NDMMS)환자60례,당뇨병대사종합정(metabolic syndrome with diabetes mellitus,DMMS)환자60례,대소유연구대상행상관혈액생화검사,ELISA법검측연구대상혈장중sRAGE수평,용법국강보악동맥경화측량의검측경고동맥맥박파전도속(carotid-femoral pulse wave velocity,CFPWV).다조간균수비교채용방차분석,조간량량비교사용LSD-t검험;sRAGE여CFPWV적상관성분석채용Pearson상관분석,채용Stepwise법진행다중선성회귀대영향CFPWV적인소진행분석;이P＜0.05위차이유통계학의의.결과 DMMS조화NDMMS조적sRAGE수평명현저우NMS조[(635.07±229.20)pg/ml vs.(671.17±358.16) pg/ml vs.(992.99 ±427.83) pg/ml,P=0.001];DMMS조적CFPWV명현고우NDMMS조여NMS조[(14.22±3.14) m/s vs.(12.15±2.79) m/svs.(11.66±2.52) m/s,P =0.002].sRAGE여CFPWV정부상관(r:-0.278,P=0.005).다중선성회귀분석현시년령(β=-0.091,95％ CI-0.096 ～-0.095,P=0.031)시CFPWV적위험인소,이HDL-C(β=1.295,95％ CI1.231 ～1.360,P=0.022)화sRAGE (β=0.119,95％ CI 0.118～0.130,P=0.032)시CFPWV적보호인소.결론 수착혈장중sRAGE수평하강MS환자대동맥강경도증가,혈장중sRAGE수평승고가능대조기혈관병변구유보호작용.
Objective investigate the correlation between plasma soluble receptor for advanced glycation endproducts (sRAGE) and arterial stiffness in patients with different types of metabolic syndrome (MS).Methods A total of 180 subjects were drawn from a epidemiologic follow-up study,including 60 cases non-metabolic syndrome (NMS),60 cases metabolic syndrome without diabetes mellitus (NDMMS),60 cases metabolic syndrome with diabetes mellitus (DMMS).Carotid femoral arterial pulse wave velocity (CFPWV) was assessed by the French KangPuLe atherosclerosis measurement instrument,and plasma sRAGE levels were measured by ELISA.Comparison of mean in multiple groups was conducted by analysis of variance.Multivariate analysis was done with multiple linear stepwise regression analysis.P ＜ 0.05 was considered as statistically significant difference.Results Compared with NMS group,plasma sRAGE levels were significantly lower in DMMS and NDMMS groups [(635.07 ± 229.20) pg/mL vs.(671.17 ± 358.16) pg/mL vs.(992.99 ± 427.83) pg/mL,P =0.001].CFPWV of DMMS group was significantly higher than that of NMDMS and NMS groups (14.22 ±3.14) m/s vs.(12.15 ±2.79) m/s vs.(11.66 ± 2.52) m/s,P =0.002).Plasma sRAGE level was negatively correlated with CFPWV (r =-0.278,P =0.005).(3) Multiple linear regression analysis demonstrated that age (β =-0.091,95％ CI-0.096 ～-0.095,P =0.031),HDL-C (β =1.295,95％ CI 1.231 ～ 1.360,P =0.022) and sRAGE (β =0.119,95％ CI 0.118 ～ 0.130,P =0.032) had a significant effect on CFPWV.Conclusions The increased arterial stiffness is closely related to the discreased plasma sRAGE levels in MS.Plasma sRAGE maybe a novel target for vascular disease prevention and treatment in patients with metabolic syndrome.
