CAJ | 학술논문

慢性脊髓压迫临床常见而预后呈多样性特点,而决定不同转归的因素和机制尚不明确.神经血管单元结构和功能变化在中枢神经系统疾病中有重要意义.基质金属蛋白酶(MMP)通过直接分解外基质、诱导胶质细胞迁徙、参与调节新生血管化、调控血脊髓屏障功能,进而影响神经血管单元稳定.MMP参与调控脊髓神经血管单元结构和功能变化可能是影响颈脊髓慢性压迫性损害转归的重要环节.
만성척수압박림상상견이예후정다양성특점,이결정불동전귀적인소화궤제상불명학.신경혈관단원결구화공능변화재중추신경계통질병중유중요의의.기질금속단백매(MMP)통과직접분해외기질、유도효질세포천사、삼여조절신생혈관화、조공혈척수병장공능,진이영향신경혈관단원은정.MMP삼여조공척수신경혈관단원결구화공능변화가능시영향경척수만성압박성손해전귀적중요배절.
Chronic spinal cord compression is the common clinical prognosis with various outcomes,but the affecting factors and mechanisms still remain unexplored.The structure and function of neurovascular unit manifest great significance in the central nervous system diseases.This paper discusses matrix metalloproteinase (MMP) impact on the stability of the neural vascular unit,by directly decomposing extracellular matrix,inducing the glial cell migration,activating angiogenesis,regulating function of blood spinal cord barrier,and put forward the MMP may be the key points in regulation of spinal cord neurovascular unit structure and function change to affect the outcome of chronic oppressive cervical spinal cord.