CAJ | 학술논문

目的评价参附注射液在治疗心脏骤停后综合征患者中的临床效果,探讨其作用机制.方法收集80例心脏骤停后自主循环恢复患者的临床资料,随机(随机数字法)分为实验组和对照组,实验组在常规治疗基础上加用参附注射液,对照组仅在常规治疗基础上加用等量生理盐水.分别对两组患者在治疗前及治疗后第3、7、14、28天进行脑功能分级(CPC)、格拉斯哥昏迷评分(Glasgow)及序贯器官衰竭估计评分(SOFA),统计两组患者呼吸机使用天数、总花费及病死率,通过统计学分析,对比两组患者经过不同治疗方案后CPC、Glasgow评分、SOFA评分、呼吸机使用总天数及总花费的差异.结果 80例患者中有3例患者病历资料不完整,从病例中剔除,最终实验组37例,对照组40例.实验组存活病例在治疗后第3、7、14、28天CPC评分较对照组低(P＜0.05);Glasgow评分实验组分别在治疗后第14、28天时较对照组高(P＜0.05).SOFA评分实验组在治疗后第3、7、14天较对照组低(P＜0.05).两组患者在治疗后第3、7、14、28天呼吸机使用天数、住院总花费比较,差异无统计学意义(P＞0.05).两组患者病死率在第3、7、14天差异无统计学意义(P＞0.05),在治疗后第28天,实验组病死率低于对照组,差异有统计学意义(P＜0.05).结论参附注射液可改善心脏骤停后综合征患者预后.
목적 평개삼부주사액재치료심장취정후종합정환자중적림상효과,탐토기작용궤제.방법 수집80례심장취정후자주순배회복환자적림상자료,수궤(수궤수자법)분위실험조화대조조,실험조재상규치료기출상가용삼부주사액,대조조부재상규치료기출상가용등량생리염수.분별대량조환자재치료전급치료후제3、7、14、28천진행뇌공능분급(CPC)、격랍사가혼미평분(Glasgow)급서관기관쇠갈고계평분(SOFA),통계량조환자호흡궤사용천수、총화비급병사솔,통과통계학분석,대비량조환자경과불동치료방안후CPC、Glasgow평분、SOFA평분、호흡궤사용총천수급총화비적차이.결과 80례환자중유3례환자병력자료불완정,종병례중척제,최종실험조37례,대조조40례.실험조존활병례재치료후제3、7、14、28천CPC평분교대조조저(P＜0.05);Glasgow평분실험조분별재치료후제14、28천시교대조조고(P＜0.05).SOFA평분실험조재치료후제3、7、14천교대조조저(P＜0.05).량조환자재치료후제3、7、14、28천호흡궤사용천수、주원총화비비교,차이무통계학의의(P＞0.05).량조환자병사솔재제3、7、14천차이무통계학의의(P＞0.05),재치료후제28천,실험조병사솔저우대조조,차이유통계학의의(P＜0.05).결론 삼부주사액가개선심장취정후종합정환자예후.
Objective To evaluate the therapeutic effects of Shenfu injection (a Chinese herbal preparation of Aconitum and Ginseng) for the treatment of patients with post-resuscitation syndrome (PCAS) and to investigate its mechanism as well.Methods The data of 80 patients with restoration of spontaneous circulation (ROSC) after cardiac arrest were collected,and the patients were randomly divided into the experimental group and the control group.The patients in experimental group received Shenfu injection in addition to conventional treatment,and the patients in control group just had the conventional treatment.The cerebral performance classification (CPC) scores,Glasgow Coma Scales cores and sequential organ failure assessment (SOFA) scores before treatment and on the 3rd,7th,14th and 28th days after treatment in the patients of two groups were monitored and compared.The length of ventilation time,total expenses and mortality of the patients were calculated and compared between two groups.Results The data of 3 patients were excluded from those of total 80 patients,because the information of those patients was not complete.Finally,there were 37 cases in experimental group and 40 patients in control group.The CPC scores of smrvived cases in experimental group were lower than those in control group on the 3rd,7th,14th and 28th days after treatment (P ＜ 0.05).The Glasgow Coma Scale scores in experimental group were higher than those in control group on the 14th and 28th days after treatment (P ＜ 0.05).The SOFA scores in experimental group were lower than those in control group on the 3rd,7th and 14th days after treatment (P ＜ 0.05).There were no significant differences in length of ventilation time and total expenses between two groups on the 3rd,7th,14th and 28th days after treatment (P ＞ 0.05).The mortality of the experimental group was lower than that in control group at the 28 th day after treatment (P ＜ 0.05).Conclusions The Shenfu injection could improve the prognosis of patients with post cardiac arrest syndrome.