中华显微外科杂志
中華顯微外科雜誌
중화현미외과잡지
Chinese Journal of Microsurgery
2015年
4期
328-333
,共6页
张光涛%姚广明%王楠%赵刚
張光濤%姚廣明%王楠%趙剛
장광도%요엄명%왕남%조강
垂体瘤%神经内镜%显微外科手术%Meta分析
垂體瘤%神經內鏡%顯微外科手術%Meta分析
수체류%신경내경%현미외과수술%Meta분석
Pituitary neoplasms%Neuro-endoscopy%Microsurgical operation%Meta-analysis
目的 通过Meta分析系统地、客观地评价内镜与显微手术在垂体瘤手术中的疗效. 方法 检索Medline、Web of Science、Google Scholar等数据库,搜集1990年1月1日至2015年5月1日的所有比较垂体瘤内镜与显微手术的随机对照研究和病例对照研究,应用R统计软件(R-3.1.3)对数据进行Meta分析.结果 共纳入22篇文献,其中随机或半随机对照研究3篇,病例对照研究19篇.研究对象共计1421人,其中内镜手术者733人,显微手术者688人.Meta分析结果显示:内镜手术的全切除率为71％,要高于显微手术的56％(P＜ 0.05),内镜手术术后激素水平恢复正常者所占比例为60％,要高于显微手术的54％,而两者差异无统计学意义(P＞0.05). 结论 就目前已有的文献来看,在垂体瘤的手术治疗上,内镜手术要优于显微手术.
目的 通過Meta分析繫統地、客觀地評價內鏡與顯微手術在垂體瘤手術中的療效. 方法 檢索Medline、Web of Science、Google Scholar等數據庫,搜集1990年1月1日至2015年5月1日的所有比較垂體瘤內鏡與顯微手術的隨機對照研究和病例對照研究,應用R統計軟件(R-3.1.3)對數據進行Meta分析.結果 共納入22篇文獻,其中隨機或半隨機對照研究3篇,病例對照研究19篇.研究對象共計1421人,其中內鏡手術者733人,顯微手術者688人.Meta分析結果顯示:內鏡手術的全切除率為71％,要高于顯微手術的56％(P＜ 0.05),內鏡手術術後激素水平恢複正常者所佔比例為60％,要高于顯微手術的54％,而兩者差異無統計學意義(P＞0.05). 結論 就目前已有的文獻來看,在垂體瘤的手術治療上,內鏡手術要優于顯微手術.
목적 통과Meta분석계통지、객관지평개내경여현미수술재수체류수술중적료효. 방법 검색Medline、Web of Science、Google Scholar등수거고,수집1990년1월1일지2015년5월1일적소유비교수체류내경여현미수술적수궤대조연구화병례대조연구,응용R통계연건(R-3.1.3)대수거진행Meta분석.결과 공납입22편문헌,기중수궤혹반수궤대조연구3편,병례대조연구19편.연구대상공계1421인,기중내경수술자733인,현미수술자688인.Meta분석결과현시:내경수술적전절제솔위71％,요고우현미수술적56％(P＜ 0.05),내경수술술후격소수평회복정상자소점비례위60％,요고우현미수술적54％,이량자차이무통계학의의(P＞0.05). 결론 취목전이유적문헌래간,재수체류적수술치료상,내경수술요우우현미수술.
Objective To evaluate the efficacy objectively and systematically between endoscopic and microscopic surgery for transsphenoidal pituitary adenoma by a Meta-analysis.Methods A systematic literature search of Medline,the Cochrane Library,the Web of Science and the Google Scholar were performed to recruit studies between January,1990 and May,2015 that compared endoscopic and microscopic approaches in the treatment of pituitary adenomas.A Meta-analysis(R-3.1.3) was conducted to estimate the effect of different operative procedures.Results A total of 22 studies including 3 randomized or quasi-randomized controlled trails and 19 case-control studies met the inclusion criteria.Among 1421 patients studied,733 of them were treated with endoscopic and 688 were treated with microscopic surgery.The rate of gross tumor removal was higher in patients who underwent endoscopic surgery (71％) than those who underwent microscopic surgery (56％)(P ＜ 0.05).The rate of remission of hypersecretion was also higher in patients who underwent endoscopic surgery(60％) than those who underwent microscopic surgery(54％),but the difference was not significantly(P ＞ 0.05).Conclusion The present study indicates that the endoscopic transsphenoidal approach is more effective than microscopic surgery in the treatment of pituitary adenomas.
