中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
17期
1-3
,共3页
刘谓%安乐美%朱清%阎磊%邵凤民
劉謂%安樂美%硃清%閻磊%邵鳳民
류위%안악미%주청%염뢰%소봉민
系统性红斑狼疮%来氟米特%治疗
繫統性紅斑狼瘡%來氟米特%治療
계통성홍반랑창%래불미특%치료
Systemic lupus erythematosus%Leflunomide%Treatment
目的 观察来氟米特治疗系统性红斑狼疮的疗效和安全性.方法 将83例系统性红斑狼疮患者随机分为观察组42例和对照组41例,在应用醋酸泼尼松基础上,观察组给予来氟米特片50 mg/d,连服3d,改为20 mg/d口服,对照组给予环磷酰胺1.0g/次,每月1次,静脉点滴.治疗6个月后评定两组疗效及不良反应发生情况,并比较两组治疗前后24h尿蛋白、血白蛋白、血肌酐、补体C3、系统性红斑狼疮疾病活动度(SLEDAI)评分.结果 观察组有效率为80.95％,对照组为78.05％,组间比较差异未见统计学意义.两组治疗后24h尿蛋白、血肌酐、SLEDAI评分均较治疗前降低,血白蛋白、补体C3水平较治疗前升高(P＜0.05);观察组与对照组比较差异未见统计学意义(P＞0.05).观察组恶心呕吐发生率(2.38％)低于对照组(29.27％),差异有统计学意义(P＜0.05),感染、转氨酶升高等不良反应发生率比较差异均未见统计学意义(P＞0.05).结论 来氟米特联合醋酸泼尼松治疗系统性红斑狼疮与环磷酰胺联合醋酸泼尼松有相当的疗效,且安全性好.
目的 觀察來氟米特治療繫統性紅斑狼瘡的療效和安全性.方法 將83例繫統性紅斑狼瘡患者隨機分為觀察組42例和對照組41例,在應用醋痠潑尼鬆基礎上,觀察組給予來氟米特片50 mg/d,連服3d,改為20 mg/d口服,對照組給予環燐酰胺1.0g/次,每月1次,靜脈點滴.治療6箇月後評定兩組療效及不良反應髮生情況,併比較兩組治療前後24h尿蛋白、血白蛋白、血肌酐、補體C3、繫統性紅斑狼瘡疾病活動度(SLEDAI)評分.結果 觀察組有效率為80.95％,對照組為78.05％,組間比較差異未見統計學意義.兩組治療後24h尿蛋白、血肌酐、SLEDAI評分均較治療前降低,血白蛋白、補體C3水平較治療前升高(P＜0.05);觀察組與對照組比較差異未見統計學意義(P＞0.05).觀察組噁心嘔吐髮生率(2.38％)低于對照組(29.27％),差異有統計學意義(P＜0.05),感染、轉氨酶升高等不良反應髮生率比較差異均未見統計學意義(P＞0.05).結論 來氟米特聯閤醋痠潑尼鬆治療繫統性紅斑狼瘡與環燐酰胺聯閤醋痠潑尼鬆有相噹的療效,且安全性好.
목적 관찰래불미특치료계통성홍반랑창적료효화안전성.방법 장83례계통성홍반랑창환자수궤분위관찰조42례화대조조41례,재응용작산발니송기출상,관찰조급여래불미특편50 mg/d,련복3d,개위20 mg/d구복,대조조급여배린선알1.0g/차,매월1차,정맥점적.치료6개월후평정량조료효급불량반응발생정황,병비교량조치료전후24h뇨단백、혈백단백、혈기항、보체C3、계통성홍반랑창질병활동도(SLEDAI)평분.결과 관찰조유효솔위80.95％,대조조위78.05％,조간비교차이미견통계학의의.량조치료후24h뇨단백、혈기항、SLEDAI평분균교치료전강저,혈백단백、보체C3수평교치료전승고(P＜0.05);관찰조여대조조비교차이미견통계학의의(P＞0.05).관찰조악심구토발생솔(2.38％)저우대조조(29.27％),차이유통계학의의(P＜0.05),감염、전안매승고등불량반응발생솔비교차이균미견통계학의의(P＞0.05).결론 래불미특연합작산발니송치료계통성홍반랑창여배린선알연합작산발니송유상당적료효,차안전성호.
Objective To investigate the efficacy and safety of leflunomide combined with prednisone in the treatment of systemic lupus erythematosus(SLE).Methods Eighty-three patients with SLE were divided into observation group(n =42) and control group(n =41).The patients in observation group were treated with prednisone plus leflunomide 50 mg/d,20 mg/d once a day after three days,orally.While the patients in control group were treated with prednisone plus cyclophosphamide 1.0 g each time,once a month,intravenous drip.The adverse effects,24-hour urine protein,serum albumin,serum creatinine,serum level of C3 and SLE disease activity index (SLEDAI)were recorded after 6-month treatment and compared between the two groups.Results The total effective rate was 80.95％ in observation group and 78.05 ％ in control group.The levels of 24-hour urine protein,serum creatinine,and SLEDAI scores were significantly decreased in both groups after the treatment than before (P ＜ 0.05).The levels of C3 and serum albumin were significantly increased in both groups after the treatment than before (P ＜ 0.05).While the incidence of nausea and vomiting was lower in observation group (2.38％) than that in control group(29.27％)(P ＜0.05).There were no significant differences in the incidence of infection or elevation of liver enzyme between the two groups (P ＞ 0.05).Conclusions Leflunomide combined with prednisone is effective on SLE.Leflunomide is generally well-tolerated in the treatment of SLE.
