中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
17期
26-27
,共2页
甲基多巴%拉贝洛尔%重度子痫前期%疗效
甲基多巴%拉貝洛爾%重度子癇前期%療效
갑기다파%랍패락이%중도자간전기%료효
Methyldopa%Labetalol%Severe pregnancy-induced hypertension%Curative effect
目的 探讨甲基多巴联合拉贝洛尔治疗重度子痫前期综合征的临床效果.方法 将新乡市妇幼保健院收治的80例重度子痫前期综合征患者随机分为观察组与对照组,每组40例.对照组给予硫酸镁治疗,观察组给予甲基多巴、拉贝洛尔联合治疗,每10分钟调整剂量以控制血压,每5小时检测心脏指数、外周阻力,比较两组的疗效及安全性.结果 治疗后观察组动脉压、24h尿蛋白、总外周阻力、脐血流分别为(135.01±14.26)mmHg(1 mm Hg=0.133 kPa)、(1.54±0.68)g/L、1.18±0.21、2.45±0.24,与治疗前比较显著下降(P＜0.05),且显著低于对照组的(171.21±14.77)mm Hg、(1.98±0.67)g/L、1.44±0.29、2.86±0.51 (P ＜0.05);观察组心脏指数高于对照组,但差异未见统计学意义(P＞0.05);观察组不良反应发生率为30.00％,显著低于对照组的70.00％,差异有统计学意义(P＜0.05).结论 甲基多巴联合拉贝洛尔治疗重度子痫前期的临床效果显著,安全性较高,具有较高的临床应用价值.
目的 探討甲基多巴聯閤拉貝洛爾治療重度子癇前期綜閤徵的臨床效果.方法 將新鄉市婦幼保健院收治的80例重度子癇前期綜閤徵患者隨機分為觀察組與對照組,每組40例.對照組給予硫痠鎂治療,觀察組給予甲基多巴、拉貝洛爾聯閤治療,每10分鐘調整劑量以控製血壓,每5小時檢測心髒指數、外週阻力,比較兩組的療效及安全性.結果 治療後觀察組動脈壓、24h尿蛋白、總外週阻力、臍血流分彆為(135.01±14.26)mmHg(1 mm Hg=0.133 kPa)、(1.54±0.68)g/L、1.18±0.21、2.45±0.24,與治療前比較顯著下降(P＜0.05),且顯著低于對照組的(171.21±14.77)mm Hg、(1.98±0.67)g/L、1.44±0.29、2.86±0.51 (P ＜0.05);觀察組心髒指數高于對照組,但差異未見統計學意義(P＞0.05);觀察組不良反應髮生率為30.00％,顯著低于對照組的70.00％,差異有統計學意義(P＜0.05).結論 甲基多巴聯閤拉貝洛爾治療重度子癇前期的臨床效果顯著,安全性較高,具有較高的臨床應用價值.
목적 탐토갑기다파연합랍패락이치료중도자간전기종합정적림상효과.방법 장신향시부유보건원수치적80례중도자간전기종합정환자수궤분위관찰조여대조조,매조40례.대조조급여류산미치료,관찰조급여갑기다파、랍패락이연합치료,매10분종조정제량이공제혈압,매5소시검측심장지수、외주조력,비교량조적료효급안전성.결과 치료후관찰조동맥압、24h뇨단백、총외주조력、제혈류분별위(135.01±14.26)mmHg(1 mm Hg=0.133 kPa)、(1.54±0.68)g/L、1.18±0.21、2.45±0.24,여치료전비교현저하강(P＜0.05),차현저저우대조조적(171.21±14.77)mm Hg、(1.98±0.67)g/L、1.44±0.29、2.86±0.51 (P ＜0.05);관찰조심장지수고우대조조,단차이미견통계학의의(P＞0.05);관찰조불량반응발생솔위30.00％,현저저우대조조적70.00％,차이유통계학의의(P＜0.05).결론 갑기다파연합랍패락이치료중도자간전기적림상효과현저,안전성교고,구유교고적림상응용개치.
Objective To study the clinical effect of labetalol combined with methyldopa on severe pregnancy-induced hypertension syndrome.Methods Eighty patients with severe pregnancy-induced hypertension syndrome were randomly divided into observation group and control group,with 40 cases in each group,patients in control group were treated with magnesium sulfate,patients in observation group were treated with methyldopa combined with labetalol,every 10 min adjust dose to control blood pressure,every 5 h of cardiac index,a peripheral resistance and at the same time compare curative effect and safety of two groups.Results After treatment,MAP,24 h pro,TRP,S/D was (135.01 ± 14.26) mm Hg (1 mm Hg =0.133 kPa),(1.54 ± 0.68) g/L,1.18 ± 0.21,2.45 ± 0.24 in observation group,which were decreased than before (P ＜ 0.05),and they were significantly lower than those in control group [(171.21 ± 14.77) mm Hg,(1.98 ±0.67) g/L,1.44 ±0.29,2.86 ±0.51] (P ＜0.05).The cardiac index of observation group was higher than that of control group,but the difference was not significant (P ＞ 0.05);The incidence of adverse reactions was 30.00％ in observation group,which was significantly lower than that in control group(70.00％),the difference was significant (P ＜ 0.05).Conclusions Clinical effect of methyldopa combined labetalol on severe pregnancy-induced hypertension is remarkable,the security is higher,it has high clinical value.
