CAJ | 학술논문

结核病是由结核杆菌引起的慢性传染病，是流行性最广、病死率最高的传染病之一。卡介苗是目前唯一用于预防结核病的疫苗，可预防儿童结核性脑膜炎和播散性结核病，但对青少年和成年人肺结核的预防效果不理想。目前已经研发出数十种能够诱导细胞免疫应答的新型结核病疫苗，包括结核杆菌减毒疫苗、重组卡介苗、亚单位疫苗和病毒载体疫苗。部分疫苗已进入临床试验，但有些研究结果不够理想。
결핵병시유결핵간균인기적만성전염병，시류행성최엄、병사솔최고적전염병지일。잡개묘시목전유일용우예방결핵병적역묘，가예방인동결핵성뇌막염화파산성결핵병，단대청소년화성년인폐결핵적예방효과불이상。목전이경연발출수십충능구유도세포면역응답적신형결핵병역묘，포괄결핵간균감독역묘、중조잡개묘、아단위역묘화병독재체역묘。부분역묘이진입림상시험，단유사연구결과불구이상。
Tuberculosis (TB ) is a chronic infectious disease caused by Mycobacterium tuberculosis .It is one of the infectious diseases with highest epidemicity and mortality rate .Currently , Bacille Calmette‐Guérin (BCG) is the only vaccine available against TB .It prevents children from tuber‐cular meningitis and disseminated TB ,but it has no obvious effectiveness against TB in adolescents and adults .Several TB candidate vaccines based on evoking cellular immune responses have been developed , including live attenuated mycobacterial vaccine ,recombinant BCG ,subunit vaccine and virus vector‐based vaccines .Part of them are now in the clinical trials ,but some of the results are not ideal .