蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2015年
9期
1166-1170
,共5页
侯传云%赵萍%江超%李志军
侯傳雲%趙萍%江超%李誌軍
후전운%조평%강초%리지군
强直性脊柱炎%白芍总苷%Meta分析
彊直性脊柱炎%白芍總苷%Meta分析
강직성척주염%백작총감%Meta분석
ankylosing spondylitis%total glucosides of paeony%Meta-analysis
目的：：对白芍总苷( TGP)治疗强直性脊柱炎( AS)的疗效及安全性进行系统评价。方法：使用循证医学方法进行文献分析。计算机检索中国期刊全文数据库、中文科技期刊全文数据库及PubMed数据库中所有有关TGP治疗AS的随机对照实验的文献,对纳入研究进行评价筛选并提取数据。使用Rev Man 5.0软件进行Meta分析。结果：共有11例随机对照实验,合计692例患者入选。与对照组比较,TGP治疗组总有效率明显升高[OR=3.36,95%CI(2.03,5.54),P<0.01],而不良反应发生率明显降低[OR=0.34,95%CI(0.21,0.53),P<0.01]；在改善C反应蛋白及Bath AS病情活动指数方面,TGP治疗组优于对照组,Meta分析结果分别为[均数差(MD)=-6.07,95%CI(-9.44,-2.70),P<0.01]和[MD=-2.66,95%CI(-5.16,-0.15),P<0.05]；在改善红细胞沉降率及Bath AS功能指数方面,2组差异均无统计学意义,Meta分析结果分别为[MD=-2.20,95%CI(-9.52,5.12),P>0.05]和[MD=-7.50,95%CI(-21.31,6.31),P>0.05]。结论：TGP治疗AS可显著增加临床治疗有效率并降低不良反应发生率。
目的：：對白芍總苷( TGP)治療彊直性脊柱炎( AS)的療效及安全性進行繫統評價。方法：使用循證醫學方法進行文獻分析。計算機檢索中國期刊全文數據庫、中文科技期刊全文數據庫及PubMed數據庫中所有有關TGP治療AS的隨機對照實驗的文獻,對納入研究進行評價篩選併提取數據。使用Rev Man 5.0軟件進行Meta分析。結果：共有11例隨機對照實驗,閤計692例患者入選。與對照組比較,TGP治療組總有效率明顯升高[OR=3.36,95%CI(2.03,5.54),P<0.01],而不良反應髮生率明顯降低[OR=0.34,95%CI(0.21,0.53),P<0.01]；在改善C反應蛋白及Bath AS病情活動指數方麵,TGP治療組優于對照組,Meta分析結果分彆為[均數差(MD)=-6.07,95%CI(-9.44,-2.70),P<0.01]和[MD=-2.66,95%CI(-5.16,-0.15),P<0.05]；在改善紅細胞沉降率及Bath AS功能指數方麵,2組差異均無統計學意義,Meta分析結果分彆為[MD=-2.20,95%CI(-9.52,5.12),P>0.05]和[MD=-7.50,95%CI(-21.31,6.31),P>0.05]。結論：TGP治療AS可顯著增加臨床治療有效率併降低不良反應髮生率。
목적：：대백작총감( TGP)치료강직성척주염( AS)적료효급안전성진행계통평개。방법：사용순증의학방법진행문헌분석。계산궤검색중국기간전문수거고、중문과기기간전문수거고급PubMed수거고중소유유관TGP치료AS적수궤대조실험적문헌,대납입연구진행평개사선병제취수거。사용Rev Man 5.0연건진행Meta분석。결과：공유11례수궤대조실험,합계692례환자입선。여대조조비교,TGP치료조총유효솔명현승고[OR=3.36,95%CI(2.03,5.54),P<0.01],이불량반응발생솔명현강저[OR=0.34,95%CI(0.21,0.53),P<0.01]；재개선C반응단백급Bath AS병정활동지수방면,TGP치료조우우대조조,Meta분석결과분별위[균수차(MD)=-6.07,95%CI(-9.44,-2.70),P<0.01]화[MD=-2.66,95%CI(-5.16,-0.15),P<0.05]；재개선홍세포침강솔급Bath AS공능지수방면,2조차이균무통계학의의,Meta분석결과분별위[MD=-2.20,95%CI(-9.52,5.12),P>0.05]화[MD=-7.50,95%CI(-21.31,6.31),P>0.05]。결론：TGP치료AS가현저증가림상치료유효솔병강저불량반응발생솔。
Objective:To analyze the therapeutic effects of total glucosides of paeony ( TGP ) for ankylosing spondylitis ( AS ) . Methods:By literature analysis based on evidence-based medicine,randomized controlled trials about TGP in the treatment of AS were obtained from Chine National Knowledge infrastructure,VIP and PubMed. Evaluated the quality of included studies and extracted the data. Rev Man 5. 0 software was used for Meta analysis. Results:Eleven randomized controlled trials with a total of 692 patients were included. Results of meta-analysis showed that the total effective rate of TGP group was higher than that of control group, and the difference was statistically significant[OR=3. 36,95%CI(2. 03,5. 54),P<0. 01]. As to the adverse reaction,the TGP group has a rather lower incidence than that of control group,and the difference was statistically significant[OR=0. 34,95%CI(0. 21,0. 53),P<0. 01]. At the same time,statistical significances were found in reducing C-reactive protein and Bath ankylosing spondylitis disease activity index between these two groups,result of Meta-analysis is[MD= -6. 07,95%CI( -9. 44,-2. 70),P<0. 01] and[MD=-2. 66,95%CI( -5. 16,-0. 15),P<0. 05] respectively. No statistically difference was found in reducing erythrocyte sedimentation rate and Bath ankylosing spondylitis functional index between these two groups,result of Meta-analysis is[MD = -2. 20,95%CI ( -9. 52,5. 12),P>0. 05] and[MD= -7. 50,95%CI( -21. 31,6. 31),P>0. 05] respectively. Conclusions:TGP can improve clinical efficient and reduce adverse reaction significantly.
