中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2015年
17期
876-880
,共5页
宋娟(综述)%叶小群(审校)
宋娟(綜述)%葉小群(審校)
송연(종술)%협소군(심교)
Hippo通路%YAP%肿瘤%G蛋白偶联受体%维替泊芬%二甲双胍
Hippo通路%YAP%腫瘤%G蛋白偶聯受體%維替泊芬%二甲雙胍
Hippo통로%YAP%종류%G단백우련수체%유체박분%이갑쌍고
Hippo pathway%YAP%tumor%G protein coupled receptors%verteporfin%metformin
Hippo通路是一个可调控细胞增殖和凋亡的信号转导通路，YAP（Yes-associated protein）为其主要效应分子。YAP为一个候选致癌因子，Hippo-YAP通路的异常与多种肿瘤的发生、发展密切相关。因此，以Hippo-YAP通路为靶点的治疗策略可能为肿瘤治疗提供新思路。一些可调控Hippo-YAP通路活性的药物/化合物如维替泊芬，可抑制肿瘤的发生或生长。本文主要对Hippo-YAP信号通路为靶点的肿瘤治疗研究进展进行综述。
Hippo通路是一箇可調控細胞增殖和凋亡的信號轉導通路，YAP（Yes-associated protein）為其主要效應分子。YAP為一箇候選緻癌因子，Hippo-YAP通路的異常與多種腫瘤的髮生、髮展密切相關。因此，以Hippo-YAP通路為靶點的治療策略可能為腫瘤治療提供新思路。一些可調控Hippo-YAP通路活性的藥物/化閤物如維替泊芬，可抑製腫瘤的髮生或生長。本文主要對Hippo-YAP信號通路為靶點的腫瘤治療研究進展進行綜述。
Hippo통로시일개가조공세포증식화조망적신호전도통로，YAP（Yes-associated protein）위기주요효응분자。YAP위일개후선치암인자，Hippo-YAP통로적이상여다충종류적발생、발전밀절상관。인차，이Hippo-YAP통로위파점적치료책략가능위종류치료제공신사로。일사가조공Hippo-YAP통로활성적약물/화합물여유체박분，가억제종류적발생혹생장。본문주요대Hippo-YAP신호통로위파점적종류치료연구진전진행종술。
Hippo pathway is a signaling network involved in the regulation of cell proliferation and apoptosis, whereas Yes-asso-ciated protein (YAP) is the major effector of the pathway. YAP is a candidate oncogene, and dysregulation of the Hippo-YAP pathway is closely related to the occurrence and progression of various tumors. Therefore, Hippo-YAP may provide a novel therapeutic target for cancer treatment. Some drugs or compounds that regulate the Hippo-YAP pathway activity, such as verteporfin, can inhibit the occur-rence or growth of tumors. This review mainly focuses on the progress of studies on the use of Hippo-YAP signaling pathway as a tar-get of cancer treatment strategies.
