中国养兔
中國養兔
중국양토
CHINESE JOURNAL OF RABBIT FARMING
2015年
4期
11-13
,共3页
陈亚萍%赵振升%王国永%吕乐义
陳亞萍%趙振升%王國永%呂樂義
진아평%조진승%왕국영%려악의
抗生素后效应%多西环素%最小抑菌浓度
抗生素後效應%多西環素%最小抑菌濃度
항생소후효응%다서배소%최소억균농도
Postantibiotic effect(PAE)%Doxycycline%Minimal inhibitory concentration(MIC)
本试验的目的是观察多西环素对大肠埃希氏菌临床分离株的体外抗菌效果,以及其抗生素后效应(PAE)。试验采用标准肉汤二倍试管稀释法测定体外最小抑菌浓度(MIC),并在MIC的基础上采用菌落计数法分别测定多西环素0.5、1、2、4倍MIC时对细菌的PAE。结果显示,多西环素对临床分离株的MIC为16μg∕mL,在0.5、1、2、4倍MIC时对大肠埃希氏菌临床分离株的PAE分别为0.5 h、1 h、2.5 h和3.5 h。结果表明,多西环素对大肠埃希氏菌临床分离株有明显的PAE,且PAE随药物浓度增大而延长。
本試驗的目的是觀察多西環素對大腸埃希氏菌臨床分離株的體外抗菌效果,以及其抗生素後效應(PAE)。試驗採用標準肉湯二倍試管稀釋法測定體外最小抑菌濃度(MIC),併在MIC的基礎上採用菌落計數法分彆測定多西環素0.5、1、2、4倍MIC時對細菌的PAE。結果顯示,多西環素對臨床分離株的MIC為16μg∕mL,在0.5、1、2、4倍MIC時對大腸埃希氏菌臨床分離株的PAE分彆為0.5 h、1 h、2.5 h和3.5 h。結果錶明,多西環素對大腸埃希氏菌臨床分離株有明顯的PAE,且PAE隨藥物濃度增大而延長。
본시험적목적시관찰다서배소대대장애희씨균림상분리주적체외항균효과,이급기항생소후효응(PAE)。시험채용표준육탕이배시관희석법측정체외최소억균농도(MIC),병재MIC적기출상채용균락계수법분별측정다서배소0.5、1、2、4배MIC시대세균적PAE。결과현시,다서배소대림상분리주적MIC위16μg∕mL,재0.5、1、2、4배MIC시대대장애희씨균림상분리주적PAE분별위0.5 h、1 h、2.5 h화3.5 h。결과표명,다서배소대대장애희씨균림상분리주유명현적PAE,차PAE수약물농도증대이연장。
The purpose of this study is to observe the antimicrobial effect and the postantibiotic effect (PAE) of doxycycline to the E. coli isolated from clinic case. The double broth dilution method was adopted to detect the minimal inhibitory concentration (MIC) of doxycycline in the experiments. The PAE of 0.5, 1, 2, 4 times of MIC to the bacteria was detected by using colony counting method. The results showed that the MIC of doxycycline was 16μg∕mL and the PAE of doxycycline in the different concentration were 0.5h, 1h, 2.5h and 3.5h respec?tively for E . coli isolated from clinic case. It suggested that the doxycycline to E. coli isolated from clinic case had an obvious PAE. The PAE was able to prolong following the increase of drug concentration.