CAJ | 학술논문

目的：研究乌司他丁在糖尿病肾脏疾病患者冠状动脉造影术后对肾的保护作用。方法选取2014年3月～2015年3月期间在我院行冠状动脉造影术的糖尿病肾脏疾病患者62例，分为两组，研究组自造影之日起静滴乌司他丁，对照组仅静滴氯化钠，分析两组对肾保护的作用。结果造影后，研究组SCr升高比例、冠状动脉造影后造影剂肾病发生率等均低于对照组，比较差异有统计学意义（P＜0.05）；造影后第1日，两组SCr、Cys C水平均呈明显上升趋势，与造影前比较有统计学的意义（P＜0.05）；但研究组造影后第7日SCr、Cys C水平上升的幅度明显低于对照组，比较有统计学意义（P＜0.05）。结论乌司他丁能够进一步降低糖尿病肾脏疾病患者冠状动脉造影术后SCr、Cys C水平，保护肾功能，具有较高的临床应用价值。
목적：연구오사타정재당뇨병신장질병환자관상동맥조영술후대신적보호작용。방법선취2014년3월～2015년3월기간재아원행관상동맥조영술적당뇨병신장질병환자62례，분위량조，연구조자조영지일기정적오사타정，대조조부정적록화납，분석량조대신보호적작용。결과조영후，연구조SCr승고비례、관상동맥조영후조영제신병발생솔등균저우대조조，비교차이유통계학의의（P＜0.05）；조영후제1일，량조SCr、Cys C수평균정명현상승추세，여조영전비교유통계학적의의（P＜0.05）；단연구조조영후제7일SCr、Cys C수평상승적폭도명현저우대조조，비교유통계학의의（P＜0.05）。결론오사타정능구진일보강저당뇨병신장질병환자관상동맥조영술후SCr、Cys C수평，보호신공능，구유교고적림상응용개치。
ObjectiveTo analyze the protective effect of ulinastatin in the patients with diabetic kidney disease after coronary angiography.Methods 62 cases of diabetic kidney disease patients who were given the treatment of coronary angiography in our hospital from March 2014 to March 2015 were chosen and divided into two groups,the research group and control group.The patients in the research group had been given intravenous ulinastatin from the date of radiography while those in the control group had been given only given intravenous sodium chloride.Protection of renal function of the two groups was analyzed.Results After imaging,the increased proportion of SCr,incidence of contrast-induced nephropathy after coronary angiography were lower than that of the control group,the differences were statistically significant(P<0.05);After the first day,levels of SCr and Cys C in the two groups were obviously rising, the differences were statistically significant than before(P<0.05);But seven days later,the extent levels of SCr and Cys C were significantly lower than that of the control group(P<0.05).ConclusionUlinastatin can further reduce SCr and Cys C level of the patients with diabetic kidney disease after coronary artery angiography, and protect the renal function.As a consequence,Ulinastatin has a rather high value in clinical application.