CAJ | 학술논문

目的：探讨糖尿病患者的胰岛功能与低血钙引起骨质疏松病变的关系。方法：采用双能 X 线骨密度测定仪测定50例2型糖尿病患者（DM 组）及42例对照组（NC 组）正位腰椎（L2～L4），双侧股骨的骨密度，并对比两项测定的临床指标。结果：患有骨质疏松的糖尿病患者较未患骨质疏松的糖尿病患者病程明显延长，空腹血清胰岛素（Fins）、C 肽以及餐后2h 血清胰岛素、C 肽明显降低（P＜0．05）。糖尿病患者双侧股骨 BMD 水平相比正常对照组下降，第3～4腰椎的 BMD 水平以及血钙水平则显著低于正常对照组（P＜0．05）。多元回归分析显示：糖尿病患者空腹血糖以及HbA1c 、病程与 BMD 负相关（P ＝0．014、0．018、0．003），体重指数、空腹血清胰岛素、餐后2h 血清胰岛素与 BMD 呈正相关（ P ＝0．012、0．021、0．006）、餐后2hC 肽和 BMD 有呈现正相关的关系。除餐后2hC 肽之外，其他的临床检验信息和 BMD 无明显关系。结论：2型糖尿病患者较正常人容易发生骨质疏松，且骨密度降低可能是由于胰岛素缺乏所导致。
목적：탐토당뇨병환자적이도공능여저혈개인기골질소송병변적관계。방법：채용쌍능 X 선골밀도측정의측정50례2형당뇨병환자（DM 조）급42례대조조（NC 조）정위요추（L2～L4），쌍측고골적골밀도，병대비량항측정적림상지표。결과：환유골질소송적당뇨병환자교미환골질소송적당뇨병환자병정명현연장，공복혈청이도소（Fins）、C 태이급찬후2h 혈청이도소、C 태명현강저（P＜0．05）。당뇨병환자쌍측고골 BMD 수평상비정상대조조하강，제3～4요추적 BMD 수평이급혈개수평칙현저저우정상대조조（P＜0．05）。다원회귀분석현시：당뇨병환자공복혈당이급HbA1c 、병정여 BMD 부상관（P ＝0．014、0．018、0．003），체중지수、공복혈청이도소、찬후2h 혈청이도소여 BMD 정정상관（ P ＝0．012、0．021、0．006）、찬후2hC 태화 BMD 유정현정상관적관계。제찬후2hC 태지외，기타적림상검험신식화 BMD 무명현관계。결론：2형당뇨병환자교정상인용역발생골질소송，차골밀도강저가능시유우이도소결핍소도치。
Objective :To study the relationship of sslet function of diabetes patients and low blood calci‐um induced osteoporosis .Methods :Select 50 cases of type 2 diabetes mellitus patients (DM group) and 42 cases of control group (NC group) ,using dual‐energy X‐ray absorptiometry (dxa) for determination of bone mineral density of the lumbar (L2 ~ L4 ) ,bilateral femur (femoral neck ,big rotor ,intertrochanteric) ,and clinical indicators were measured .Results :Diabetic osteoporosis patients compared with non diabetic osteoporosis patients ,duration was obviously extended ,fasting serum insulin (Fins) ,c‐peptide and postprandial 2 h level were significantly lower ,the differences between groups were statistically significant , P < 0 .05) .Bilateral femur BMD level of diabetes patients had a different degree of decline compare with normal control group ,3 ~ 4 lumbar BMD level and blood calcium lev‐els were significantly lower than normal control group , P< 0 .05) .Multiple regression analysis showed that fasting blood glucose (FBG) in diabetic patients was negatively correlated with BMD (P = 0 .014) ,HbA1c was negatively correlated with BMD (P = 0 .018) ,the clinical course of diabetes was negatively correlated with BMD ( P = 0 . 003) ,body mass index and BMD was positively correlated (P = 0 .012) ,fasting serum insulin and BMD was posi‐tively correlated (P = 0 .021) ,postprandial 2 h serum insulin and BMD was positively correlated (P = 0 .014) , fasting C peptide was positively correlated with BMD (P = 0 .006) ,postprandial 2 hc peptide was positively correla‐ted with BMD (P = 0 .010) .The rest clinical data had no significant correlation with BMD .Conclusion :Type 2 di‐abetes patients are prone to osteoporosis than normal people ,bone mineral density decrease may be due to a lack of insulin .