中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
22期
140-141
,共2页
甲氨蝶呤%类风湿性关节炎%痛觉阀%疗效
甲氨蝶呤%類風濕性關節炎%痛覺閥%療效
갑안접령%류풍습성관절염%통각벌%료효
Methotrexate%Rheumatoid arthritis%Pain valve%Curative effect
目的：研究甲氨蝶呤治疗类风湿性关节炎(RA)的疗效及对患者痛觉的影响。方法以该院2012年6月-2014年6月诊治的120例类风湿性关节炎患者为研究对象，随机双盲法将其分为两组，各60例，对照组采取安慰剂治疗，观察组给予甲氨蝶呤治疗，比较两组临床疗效、不良反应、治疗前后晨僵时间、关节肿胀数、关节压痛数、痛觉阀(PPT)、类风湿因子(RF)等指标。结果观察组总有效率、不良反应发生率分别为90.00%、10.0%，较对照组的65.0%、33.3%差异有统计学意义(P<0.05)。观察组治疗后晨僵时间、关节肿胀数、关节压痛数明显少于对照组，差异有统计学意义(P<0.05)。两组治疗后ESR、CRP、PPT、RF比较差异有统计学意义(P<0.01)。结论甲氨蝶呤治疗RA疗效明确，能明显改善患者临床症状及体征，值得临床推广。
目的：研究甲氨蝶呤治療類風濕性關節炎(RA)的療效及對患者痛覺的影響。方法以該院2012年6月-2014年6月診治的120例類風濕性關節炎患者為研究對象，隨機雙盲法將其分為兩組，各60例，對照組採取安慰劑治療，觀察組給予甲氨蝶呤治療，比較兩組臨床療效、不良反應、治療前後晨僵時間、關節腫脹數、關節壓痛數、痛覺閥(PPT)、類風濕因子(RF)等指標。結果觀察組總有效率、不良反應髮生率分彆為90.00%、10.0%，較對照組的65.0%、33.3%差異有統計學意義(P<0.05)。觀察組治療後晨僵時間、關節腫脹數、關節壓痛數明顯少于對照組，差異有統計學意義(P<0.05)。兩組治療後ESR、CRP、PPT、RF比較差異有統計學意義(P<0.01)。結論甲氨蝶呤治療RA療效明確，能明顯改善患者臨床癥狀及體徵，值得臨床推廣。
목적：연구갑안접령치료류풍습성관절염(RA)적료효급대환자통각적영향。방법이해원2012년6월-2014년6월진치적120례류풍습성관절염환자위연구대상，수궤쌍맹법장기분위량조，각60례，대조조채취안위제치료，관찰조급여갑안접령치료，비교량조림상료효、불량반응、치료전후신강시간、관절종창수、관절압통수、통각벌(PPT)、류풍습인자(RF)등지표。결과관찰조총유효솔、불량반응발생솔분별위90.00%、10.0%，교대조조적65.0%、33.3%차이유통계학의의(P<0.05)。관찰조치료후신강시간、관절종창수、관절압통수명현소우대조조，차이유통계학의의(P<0.05)。량조치료후ESR、CRP、PPT、RF비교차이유통계학의의(P<0.01)。결론갑안접령치료RA료효명학，능명현개선환자림상증상급체정，치득림상추엄。
Objective To study the curative effect of methotrexate in treating rheumatoid arthritis and its influence on patients' sense of pain. Methods 120 patients with rheumatoid arthritis admitted into our and other hospitals from June 2012 to June 2014 for treatment were selected as the research object and were divided into two groups by the random double blind method with 60 cases in each. The control group was treated with placebo while the observation group with methotrexate. Indicators such as the clinical curative effect, adverse reaction, time of morning stiffness before and after the treatment, number of arthrocele, tender joint count, pain valve (PPT) and rheumatoid factor (RF) of the two groups were compared. Results In the observation group, the total efficiency and the occurrence rate of adverse reactions respectively were 90.00%and 10.0%. Compared with 65.0%and 33.3%of the control group, the difference was statistically significant (P<0.05). In the observation group after the treatment, the time of morning stiffness, number of arthrocele and tender joint count were significantly less than those of the control group and the differ-ence was statistically significant (P<0.05). The contrast differences in ESR, CRP, PPT and RF of the two groups after the treatment were statistically significant (P<0.01). Conclusion The curative effect of methotrexate in the treatment of RA is definite. It can sig-nificantly improve the clinical symptoms and signs of patients, worthy of promotion.
