CAJ | 학술논문

正畸矫治器多为金属制品且含多种金属成分，其中的镍、铬、铜和银等离子含量过高对细胞有一定的影响，因此对其生物安全性检测必不可少。镍含量小于5%的金属托槽同样具有细胞毒性，影响细胞的形态和增殖。铜和锌离子颊管也具有较强的细胞毒性作用。影响金属离子释放的主要因素有金属的组成、表面结构和蛋白质以及浸提液类型、浸提时间、浸提液pH等。目前，彗星试验和微核试验是常用的细胞基因毒性检测方法，二者用以检测细胞的基因毒性，可起到互补的作用。本文就正畸金属矫治器的毒性，正畸金属矫治器的离子释放，正畸金属材料的细胞毒性和基因毒性等研究进展作一综述，旨在为后续研究提供参考。
정기교치기다위금속제품차함다충금속성분，기중적얼、락、동화은등리자함량과고대세포유일정적영향，인차대기생물안전성검측필불가소。얼함량소우5%적금속탁조동양구유세포독성，영향세포적형태화증식。동화자리자협관야구유교강적세포독성작용。영향금속리자석방적주요인소유금속적조성、표면결구화단백질이급침제액류형、침제시간、침제액pH등。목전，혜성시험화미핵시험시상용적세포기인독성검측방법，이자용이검측세포적기인독성，가기도호보적작용。본문취정기금속교치기적독성，정기금속교치기적리자석방，정기금속재료적세포독성화기인독성등연구진전작일종술，지재위후속연구제공삼고。
Most?orthodontic?appliances?are?metal?and?contain?many?metal?elements,?such?as?nickel,?chromium,?copper,?and?silver,?which?have?been?confirmed?to?be?cytotoxic?at?high?concentrations.?Thus,?the?biosecurity?of?these?metals?needs?to?be?tested.?Metal?brackets?with?concentrations?of?less?than?5%?nickel?have?also?been?confirmed?to?be?cytotoxic.?These?brackets,?such?as?metal?buccal?tube?with?copper?and?zinc,?affect?cell?morphology?and?proliferation.?The?factors?affecting?the?release?of?metal?ions?are?as?follows:?metal?elements,?surface?structure,?protein,?immersing?category,?immersing?time,?and?immersing?potential?of?hydrogen.?Currently,?the?complementary?methods?of?Comet?and?micronuclear?tests?are?mainly?used?to?test?genotoxicity.?This?article?aimed?to?discuss?the?cytotoxicity?and?genotoxicity?of?metal?orthodontic?appliances?in?terms?of?ion?release,?as?well?as?study?cytotoxicity?and?genotoxicity.?This?article?will?offer?reference?for?others.