CAJ | 학술논문

c-Jun?N-末端激酶（JNK）是促丝裂原激活蛋白激酶家族成员，转导细胞外信号为细胞内反应。JNK信号通路主要被细胞因子和应激刺激激活，调节细胞迁移，参与细胞增殖、分化、炎症和程序性死亡。细胞迁移机制与细胞骨架、黏着斑、黏着斑激酶、整联蛋白、鼠肉瘤病毒同源癌基因家族蛋白、G-蛋白和水通道蛋白等紧密相关，但其调控机制尚不清楚。目前JNK通路调节细胞迁移的研究显示：在上皮和成纤维细胞，JNK信号通路被活化，可促进细胞迁移，增强伤口愈合、组织修复；在肿瘤细胞，JNK信号通路被抑制可降低肿瘤细胞的迁移能力；在炎症环境下，JNK的作用与机制表现出差异性，有待进一步研究。诠释JNK信号转导通路参与调节细胞迁移的具体机制可为组织修复、炎症控制和肿瘤治疗提供新的思路。
c-Jun?N-말단격매（JNK）시촉사렬원격활단백격매가족성원，전도세포외신호위세포내반응。JNK신호통로주요피세포인자화응격자격격활，조절세포천이，삼여세포증식、분화、염증화정서성사망。세포천이궤제여세포골가、점착반、점착반격매、정련단백、서육류병독동원암기인가족단백、G-단백화수통도단백등긴밀상관，단기조공궤제상불청초。목전JNK통로조절세포천이적연구현시：재상피화성섬유세포，JNK신호통로피활화，가촉진세포천이，증강상구유합、조직수복；재종류세포，JNK신호통로피억제가강저종류세포적천이능력；재염증배경하，JNK적작용여궤제표현출차이성，유대진일보연구。전석JNK신호전도통로삼여조절세포천이적구체궤제가위조직수복、염증공제화종류치료제공신적사로。
C-Jun?N-terminal?kinase(JNK)?is?a?member?of?the?mitogen-activated?protein?kinase?family,?which?regulates?diverse?cellular?programs?by?relaying?extracellular?signals?to?intracellular?responses.?Activated?primarily?by?cytokines?and?environmental?stress,?the?JNK?signal?transduction?pathway?regulates?cell?migration?and?plays?an?important?role?in?cellular?proliferation,?differentiation,?inflammatory?response,?and?apoptosis.?The?mechanism?of?cell?migration?is?closely?related?to?the?cytoskeleton,?focal?adhesion,?focal?adhesion?kinase,?integrin,?and?ras?homology?oncogene?family?proteins,?G-protein,?and?aquaporin.?Recent?research?on?JNK?pathway?regulating?cell?migration?shows?that?the?activation?of?the?JNK?signaling?pathway?can?promote?epithelial?cell?and?fibroblast?migration?and?can?enhance?wound?healing?and?tissue?repair.?Inhibiting?the?JNK?signaling?pathway?can?reduce?cell?migration?and?invasion?in?tumor?cells.?The?function?and?mechanism?of?JNK?in?inflammation?are?controversial.?Discovering?the?specific?mechanisms?underlying?the?activities?of?the?JNK?signal?transduction?pathway,?which?is?involved?in?regulating?cell?migration,?can?provide?new?ideas?for?tissue?repair,?inflammation?control,?and?tumor?treatment.