CAJ | 학술논문

利用中国知网、万方、维普、PubMed数据库，系统检索1949年以来关于“十八反”中海藻甘草反药组合同用的研究文献，检索过程中剔除综述及临床研究类文章，选取实验研究方面的文章，总结归纳海藻甘草反药组合配伍使用的适宜和禁忌条件。初步认为海藻与甘草1：1、1：2、1：3配伍为适宜条件，海藻与甘草3：1比例以及大于3：1比例配伍为禁忌条件，并且随着海藻剂量增加，毒性增强。应用于特定病理模型下的海藻玉壶汤中，为海藻甘草配伍适宜条件。现有文献显示，短时间给药为配伍适宜条件；腹腔注射以及长时间给药为配伍禁忌条件。而煎煮方法、不同品种方面的研究较少，很难从少量的实验中总结归纳出宜忌条件。因此海藻甘草能否同用不能一概而论，而是受到不同条件的限制。今后应当进一步开展不同品种的药用海藻与甘草配伍的宜忌条件研究，增加多条件、多层次交叉研究，完善海藻甘草反药组合配伍的宜忌条件，以期为临床安全用药提供重要的实验依据。
이용중국지망、만방、유보、PubMed수거고，계통검색1949년이래관우“십팔반”중해조감초반약조합동용적연구문헌，검색과정중척제종술급림상연구류문장，선취실험연구방면적문장，총결귀납해조감초반약조합배오사용적괄의화금기조건。초보인위해조여감초1：1、1：2、1：3배오위괄의조건，해조여감초3：1비례이급대우3：1비례배오위금기조건，병차수착해조제량증가，독성증강。응용우특정병리모형하적해조옥호탕중，위해조감초배오괄의조건。현유문헌현시，단시간급약위배오괄의조건；복강주사이급장시간급약위배오금기조건。이전자방법、불동품충방면적연구교소，흔난종소량적실험중총결귀납출의기조건。인차해조감초능부동용불능일개이론，이시수도불동조건적한제。금후응당진일보개전불동품충적약용해조여감초배오적의기조건연구，증가다조건、다층차교차연구，완선해조감초반약조합배오적의기조건，이기위림상안전용약제공중요적실험의거。
This article summarized the suitable conditions and contraindicant conditions of antagonism compatibility sargassum and glycyrrhiza from the selected experimental research articles by searching“Sargassum and Radix Glycyrrhizae compatibility of Chinese medicine Eighteen antagonism” from Wan Fang, CNKI, and VIP database since 1949. The efficacy and toxicity of the anti-drug combination are affected by many conditions, including proportion, dose, extracting manner, prepared varieties and route of administration. We can concluded from literatures that it ’ s suitable when the ratios of sargassum and glycyrrhiza are 1:1,1:2 or 1:3;while the contraindicant conditions are when the ratios are 3:1 or higher than 3:1, or injecting intraperitoneally for a long time. Therefore, whether sargassum and glycyrrhizae can be used together or not is affected by different conditions. In the future, we can make more researches on it to enrich suitable and contraindicant conditions for sargassum and glycyrrhiza compatibility.