CAJ | 학술논문

利用中国知网、万方、维普、PUBMED数据库，系统检索自1949年至今，有关“十八反”中乌头与半夏反药组合同用的文献，检索文章的过程中剔除综述及临床研究类文章，选取实验研究方面的文章，总结归纳乌头半夏反药组合配伍使用的宜忌条件。初步认为生川乌与生半夏1：2配伍为实验的禁忌条件，对心、肝、肾组织的损害大，各高、中、低剂量组(相当于临床成人剂量的45倍、10~15倍、3~6倍)之间无差异，就其煎煮方式而言，合煎液比合并液的毒性强；由于乌头与半夏有不同的炮制品种，即使在相同的比例下进行实验也会出现不同的结果，比例方面尚不能归纳其适宜条件。而给药时间、煎煮方式方面的研究较少，很难从少量的实验中总结归纳出宜忌条件。笔者认为乌头半夏能否同用不能一概而论，而是受到不同条件的限制。即对乌头半夏这一反药组合配伍应进行多角度、多学科、多层次的探析以期最终阐明乌头与半夏的配伍实质，为完善中药配伍理论和指导临床运用起到重要的理论意义和临床价值。
이용중국지망、만방、유보、PUBMED수거고，계통검색자1949년지금，유관“십팔반”중오두여반하반약조합동용적문헌，검색문장적과정중척제종술급림상연구류문장，선취실험연구방면적문장，총결귀납오두반하반약조합배오사용적의기조건。초보인위생천오여생반하1：2배오위실험적금기조건，대심、간、신조직적손해대，각고、중、저제량조(상당우림상성인제량적45배、10~15배、3~6배)지간무차이，취기전자방식이언，합전액비합병액적독성강；유우오두여반하유불동적포제품충，즉사재상동적비례하진행실험야회출현불동적결과，비례방면상불능귀납기괄의조건。이급약시간、전자방식방면적연구교소，흔난종소량적실험중총결귀납출의기조건。필자인위오두반하능부동용불능일개이론，이시수도불동조건적한제。즉대오두반하저일반약조합배오응진행다각도、다학과、다층차적탐석이기최종천명오두여반하적배오실질，위완선중약배오이론화지도림상운용기도중요적이론의의화림상개치。
This article summarized the suitable conditions and contraindicant conditions of antagonism compatibility aconitum and pinellia ternate from the selected experimental research articles by searching “aconite and Pinellia ternate compatibility of Chinese medicine eighteen antagonism” from Wan Fang, CNKI, and VIP database since 1949. We preliminarily concluded that when the compatibility ratio of aconitum and pinellia ternate is 1:2, the damage for heart, liver and kidney is highest. On the method of preparation, the decoction of two herbs is more toxic than the combined solutions of single herb decoction. Different processing of the two herbs give different experiment results even though on the certain ratio, so it’ s hard to conclude the optimum condition. More researches should be done to get the essence of the two-contraindicated herbs so that improving the compatibility theory of traditional Chinese medicine and clinical value.