CAJ | 학술논문

目的：探讨分析老年2型糖尿病患者的甲状腺激素水平的变化和临床意义。方法整群选取该院2013年11月-2014年11月间前来就诊的54例老年2型糖尿病患者作为研究组，同期体检的54例非糖尿病健康老年人作为对照组，检测两组的三碘甲状腺氨酸(TT3)、甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、反三碘甲腺原氨酸甲状腺激素(rT3)、促甲状腺激素(TSH)及抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(TGAb)水平。结果研究组患者游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)及促甲状腺激素(TSH)均低于对照组水平，反三碘甲腺原氨酸甲状腺激素(rT3)、抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(TGAb)均高于对照组水平，差异具有统计学意义(P<0.05)。结论老年2型糖尿病患者甲状腺激素偏离正常水平，二者相互作用可导致病情恶性循环进展，因此对老年2型糖尿病患者进行甲状腺激素水平监测、干预具有重要的临床意义。
목적：탐토분석노년2형당뇨병환자적갑상선격소수평적변화화림상의의。방법정군선취해원2013년11월-2014년11월간전래취진적54례노년2형당뇨병환자작위연구조，동기체검적54례비당뇨병건강노년인작위대조조，검측량조적삼전갑상선안산(TT3)、갑상선소(TT4)、유리삼전갑상선원안산(FT3)、유리사전갑상선원안산(FT4)、반삼전갑선원안산갑상선격소(rT3)、촉갑상선격소(TSH)급항갑상선과양화물매항체(TPOAb)、항갑상선구단백항체(TGAb)수평。결과연구조환자유리삼전갑상선원안산(FT3)、유리사전갑상선원안산(FT4)급촉갑상선격소(TSH)균저우대조조수평，반삼전갑선원안산갑상선격소(rT3)、항갑상선과양화물매항체(TPOAb)、항갑상선구단백항체(TGAb)균고우대조조수평，차이구유통계학의의(P<0.05)。결론노년2형당뇨병환자갑상선격소편리정상수평，이자상호작용가도치병정악성순배진전，인차대노년2형당뇨병환자진행갑상선격소수평감측、간예구유중요적림상의의。
Objective To analyze the change of thyroid hormone level in elderly patients with type 2 diabetes and its clinical sig-nificance. Methods 54 elderly patients with type 2 diabetes admitted in our hospital during November 2013 and November 2014 were assigned to the study group, and 54 healthy elderly without diabetes in the same period were assigned to the control group. Total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), free thyroxine (FT4), reverse triiodothyronine (rT3), thyroid stimulating hormone (TSH), antithyroperoxidase antibody (TPOAb) and anti-Thyroglobulin antibody (TGAb) level of the patients were determined in the two groups. Results FT3, FT4, TSH level were lower and rT3, TPOAb, TGAb level higher in the study group than in the control group, and the differences were statistically significant,P<0.05. Conclusion The combination of type 2 diabetes and abnormal thyroid hormone level can lead to disease progression, therefore it is of clinical significance to deter-mine the thyroid hormone level for elderly patients.