CAJ | 학술논문

主要外鞘蛋白（Mosp）广泛存在于密螺旋体的菌体表面，常以低聚物的形式存在，分别由葡萄糖、半乳糖、谷氨酰胺、氨基半乳糖和岩藻糖组成。Mosp的中央结构域，在介导细菌与宿主蛋白的黏附中起着至关重要的作用。Mosp竞争性地抑制齿垢密螺旋体与具核梭杆菌和牙龈卟啉单胞菌的结合，即Mosp在齿垢密螺旋体与牙周致病菌共聚中起着类黏附蛋白的作用。Mosp的细胞毒性即成孔效应，包括营养摄取，转运细菌产物至感染的宿主细胞，介导细胞的杀伤作用。Mosp可通过影响成纤维细胞、中性粒细胞的细胞骨架破坏其迁移运动能力，而成纤维细胞的迁移与牙周结缔组织的改建和愈合相关，中性粒细胞又是牙周固有免疫的关键细胞，可牵制致病菌的扩散。深入研究Mosp的作用机制，可为降低齿垢密螺旋体的致病性提供新的思路，为控制牙周炎的进展奠定坚实的理论基础。
주요외초단백（Mosp）엄범존재우밀라선체적균체표면，상이저취물적형식존재，분별유포도당、반유당、곡안선알、안기반유당화암조당조성。Mosp적중앙결구역，재개도세균여숙주단백적점부중기착지관중요적작용。Mosp경쟁성지억제치구밀라선체여구핵사간균화아간계람단포균적결합，즉Mosp재치구밀라선체여아주치병균공취중기착류점부단백적작용。Mosp적세포독성즉성공효응，포괄영양섭취，전운세균산물지감염적숙주세포，개도세포적살상작용。Mosp가통과영향성섬유세포、중성립세포적세포골가파배기천이운동능력，이성섬유세포적천이여아주결체조직적개건화유합상관，중성립세포우시아주고유면역적관건세포，가견제치병균적확산。심입연구Mosp적작용궤제，가위강저치구밀라선체적치병성제공신적사로，위공제아주염적진전전정견실적이론기출。
The?major?outer?sheath?protein(Mosp),?which?consists?of?glucose,?galactose,?glutamine,?galactosamine,?and?fucose,?is?the?most?abundant?outer?membrane?protein?on?the?cell?surface?of Treponema denticola(T.denticola)?at?low?molecular?polymer?form.?The?central?domain?of?Mosp?plays?a?significant?role?in?the?adhesion?of?bacteria?and?the?host?proteins.?Mosp?also?acts?as?an?adhesion?to?some?extent,?thereby?competitively?inhibiting?the?combination?of?T.denticola,?Porphyromonas gingivalis,?and?Fusobacterium nucleatum.?Cytotoxicity?is?another?contributing?factor?that?allows?the?bacteria?to?obtain?nutrients,?transport?bacterial?products?to?the?infected?host?cells,?and?mediate?cytotoxic?activity.?Furthermore,?the?Mosp?can?destroy?the?migration?of?fibroblasts?and?neutrophils.?However,?the?migration?of?fibroblasts?is?closely?related?to?reconstruction?and?healing?in?periodontal?connective?tissues,?whereas?neutrophils?play?key?roles?in?the?periodontal?innate?immune?system,?thereby?enabling?neutrophils?to?limit?the?spread?of?pathogens.?Understanding?the?mechanism?underlying?Mosp?activity?may?provide?new?insights?intothe?reduction?of T.denticola?pathogenicity?and?may?lay?a?solid?theoretical?foundation?fordelaying?the?progression?of?periodontitis.