陕西医学杂志
陝西醫學雜誌
협서의학잡지
SHAANXI MEDICAL JOURNAL
2015年
9期
1175-1177
,共3页
肾功能衰竭 ,急性/药物疗法%前列地尔/治疗应用%谷胱甘肽/治疗应用%还原剂
腎功能衰竭 ,急性/藥物療法%前列地爾/治療應用%穀胱甘肽/治療應用%還原劑
신공능쇠갈 ,급성/약물요법%전렬지이/치료응용%곡광감태/치료응용%환원제
Kidney failure,acute/drug therapy%Alprostadil/therapeutic use%Glutathione/therapeu-tic use%Reducing agents
目的：探讨前列地尔联合还原型谷胱甘肽治疗急性肾损伤（AKI）的临床疗效。方法：选择 AKI 患者60例随机分为观察组与对照组，对照组30例在常规治疗基础上加用还原型谷胱甘肽治疗，观察组30例在对照组基础上加用前列地尔治疗，观察两组患者治疗效果与肾功能改善情况。结果：观察组患者治愈率为86．7％（26／30），显著优于对照组的63．3％（P＜0．05）；少尿型 AKI患者少尿期、多尿期持续时间、Scr 恢复时间显著短于对照组（P ＜0．05或 P＜0．01）；Scr 、Ccr 恢复情况不同时期比较观察组显著优于对照组（P＜0．05或 P＜0．01），治疗第28天观察组尿渗透压显著高于对照组、β2‐MG 显著低于对照组（P ＜0．01）。结论：还原型谷胱甘肽联合前列地尔对 AKI患者具有确切疗效，对改善肾功能方面具有积极治疗作用，可有效提高治愈率。
目的：探討前列地爾聯閤還原型穀胱甘肽治療急性腎損傷（AKI）的臨床療效。方法：選擇 AKI 患者60例隨機分為觀察組與對照組，對照組30例在常規治療基礎上加用還原型穀胱甘肽治療，觀察組30例在對照組基礎上加用前列地爾治療，觀察兩組患者治療效果與腎功能改善情況。結果：觀察組患者治愈率為86．7％（26／30），顯著優于對照組的63．3％（P＜0．05）；少尿型 AKI患者少尿期、多尿期持續時間、Scr 恢複時間顯著短于對照組（P ＜0．05或 P＜0．01）；Scr 、Ccr 恢複情況不同時期比較觀察組顯著優于對照組（P＜0．05或 P＜0．01），治療第28天觀察組尿滲透壓顯著高于對照組、β2‐MG 顯著低于對照組（P ＜0．01）。結論：還原型穀胱甘肽聯閤前列地爾對 AKI患者具有確切療效，對改善腎功能方麵具有積極治療作用，可有效提高治愈率。
목적：탐토전렬지이연합환원형곡광감태치료급성신손상（AKI）적림상료효。방법：선택 AKI 환자60례수궤분위관찰조여대조조，대조조30례재상규치료기출상가용환원형곡광감태치료，관찰조30례재대조조기출상가용전렬지이치료，관찰량조환자치료효과여신공능개선정황。결과：관찰조환자치유솔위86．7％（26／30），현저우우대조조적63．3％（P＜0．05）；소뇨형 AKI환자소뇨기、다뇨기지속시간、Scr 회복시간현저단우대조조（P ＜0．05혹 P＜0．01）；Scr 、Ccr 회복정황불동시기비교관찰조현저우우대조조（P＜0．05혹 P＜0．01），치료제28천관찰조뇨삼투압현저고우대조조、β2‐MG 현저저우대조조（P ＜0．01）。결론：환원형곡광감태연합전렬지이대 AKI환자구유학절료효，대개선신공능방면구유적겁치료작용，가유효제고치유솔。
Objective :To discuss the clinical effects of alprostadil combined with glutathione in patients with AKI .Methods :60 patients with AKI were randomly divided into the observation group(n= 30) and the control group(n= 30) ,the control group were treated with Glutathione based on the conventional therapy ,and the observa‐tion group were given alprostadil based on the control group ,then the clinical effects were contrasted between the two groups .Results :Cure rate in the observation group was 86 .7% (26/30) ,significantly higher than 63 .3% (19/30) in the control group(P< 0 .05) ,in patients with Oliguric AKI ,Oliguria ,polyuria period duration ,and Scr re‐covery time in the observation group were significantly lower than the control group(P< 0 .05) ,in different periods , Scr and Ccr recovery in the observation group were significantly better the control group(P< 0 .05) ,Urine osmolali‐ty in the observation group was significantly higher than the control group 28 days after the treatment(P < 0 .01) , and β2‐MG significantly lower than the control group(P< 0 .01) .Conclusion :Alprostadil combined with glutathione has exactly effects in patients with AKI ,has positive therapeutic effect in the improvement of renal function ,it can effectively improve the cure rate .
