CAJ | 학술논문

目的：研究振腹对2型糖尿病大鼠血清游离脂肪酸及甘油三酯的影响。方法用高糖高脂联合小剂量链脲佐菌素建立2型糖尿病大鼠模型，最终模型组11只、低频治疗组9只、高频治疗组10只，设立12只正常大鼠为对照组，予振腹治疗6周，于治疗前后监测大鼠空腹血糖、游离脂肪酸、甘油三酯的水平。多组间差异比较采用单因素方差分析。结果治疗前，与对照组对比，其余各组大鼠空腹血糖、游离脂肪酸、甘油三酯的水平均升高(P<0.05)。治疗后，与模型组对比，低频治疗组和高频治疗组大鼠空腹血糖、游离脂肪酸、甘油三酯的水平均降低( P<0.05)；低频治疗组和高频治疗组相比较，大鼠空腹血糖、游离脂肪酸、甘油三酯的水平无明显差异( P>0.05)。结论振腹能降低2型糖尿病大鼠空腹血糖、游离脂肪酸、甘油三酯的水平，其机制可能为：(1)振腹通过调节肾上腺的分泌功能影响脂代谢；(2)增强腹部肌肉和胃肠道平滑肌运动，增加了组织对脂肪的氧化作用；(3)减少腹部及内脏脂肪异位堆积，提高腹部及内脏组织细胞胰岛素受体的敏感性。
목적：연구진복대2형당뇨병대서혈청유리지방산급감유삼지적영향。방법용고당고지연합소제량련뇨좌균소건립2형당뇨병대서모형，최종모형조11지、저빈치료조9지、고빈치료조10지，설립12지정상대서위대조조，여진복치료6주，우치료전후감측대서공복혈당、유리지방산、감유삼지적수평。다조간차이비교채용단인소방차분석。결과치료전，여대조조대비，기여각조대서공복혈당、유리지방산、감유삼지적수평균승고(P<0.05)。치료후，여모형조대비，저빈치료조화고빈치료조대서공복혈당、유리지방산、감유삼지적수평균강저( P<0.05)；저빈치료조화고빈치료조상비교，대서공복혈당、유리지방산、감유삼지적수평무명현차이( P>0.05)。결론진복능강저2형당뇨병대서공복혈당、유리지방산、감유삼지적수평，기궤제가능위：(1)진복통과조절신상선적분비공능영향지대사；(2)증강복부기육화위장도평활기운동，증가료조직대지방적양화작용；(3)감소복부급내장지방이위퇴적，제고복부급내장조직세포이도소수체적민감성。
Objective To study the influences of the vibrating abdomen on serum free fatty acids and triglyceride in rats with type 2 diabetes mellitus. Methods The rat models were established by using high sugar fatty feed combined with injection of low dose of streptozotocin, finally the rats were divided into model group (n=11), low frequency treatment group (n=9) and the high frequency treatment group (n=10), and all the treatment were lasted for 6 weeks. Another 12 normal rats were chosen as the control group. Fasting blood-glucose (FBG), free futty acid(FFA) and triglyceride(TG) were tested in pre-therapy and post-treatment, and the results were analyzed by using one-way analysis of variance. Results Compared with the control group, the levels of FBG, FFA and TG in the rest another groups were increased significantly (P< 0. 05). Compared with the model group, the levels of FBG, FFA and TG of rats in low frequency and high frequency treatment groups were decreased significantly (P<0. 05). The differences in the levels of FBG, FFA and TG were not significant between low frequency treatment group and high frequency treatment group ( P>0. 05 ) . Conclusions Vibrating abdomen could decrease the levels of FBG, FFA and TG of rats with type 2 diabetes mellitus, and the mechanism might be related with the following aspects:(1):Vibrating abdomen could influence the lipid metabolism by adjusting the secretion function of adrenal gland. (2) Vibrating abdomen could increase the lipid oxidation by strengthening the movement of abdominal muscles and gastrointestinal smooth muscles. ( 3 ) Vibrating abdomen could increase the sensitivity of insulin receptor in cells of abdomen and visceral by reducing the ectopic fat accu-mulation in abdomen and visceral.