CAJ | 학술논문

目的：探讨前列腺癌放疗中体积变化与新辅助内分泌治疗（ NHT）之间的关系。方法55例接受NHT前列腺癌患者连续入组，放疗中每周测量前列腺左右、上下、前后方向直径并计算体积。分析放疗中前列腺缩小与NHT时间、放疗前体积及前列腺癌风险分组间关系。结果所有患者前列腺体积均随放疗进行而减小，NHT时间短者各项变化幅度大于时间长者。前列腺体积正常组与增大组比，前者在放疗7周后体积变化比例及各方向直径变化幅度均较大，且放疗前NHT时间较短，前列腺癌风险较低。与放疗前相比，中低危患者NHT≤4个月的体积分别缩小至68?10％、78?70％（ P＝0?002），而＞4个月者变化较微弱；高危以上患者 NHT≤6个月的体积分别缩小至76?59％及85?46％（ P＝0?001），而＞6个月者相近。结论 NHT时间越长，放疗中前列腺体积及各方向直径变化幅度越小。中低危前列腺癌患者NHT4个月以后前列腺体积的变化幅度较小，高危或局部进展期患者NHT时间6个月以后变化幅度较小。
목적：탐토전렬선암방료중체적변화여신보조내분비치료（ NHT）지간적관계。방법55례접수NHT전렬선암환자련속입조，방료중매주측량전렬선좌우、상하、전후방향직경병계산체적。분석방료중전렬선축소여NHT시간、방료전체적급전렬선암풍험분조간관계。결과소유환자전렬선체적균수방료진행이감소，NHT시간단자각항변화폭도대우시간장자。전렬선체적정상조여증대조비，전자재방료7주후체적변화비례급각방향직경변화폭도균교대，차방료전NHT시간교단，전렬선암풍험교저。여방료전상비，중저위환자NHT≤4개월적체적분별축소지68?10％、78?70％（ P＝0?002），이＞4개월자변화교미약；고위이상환자 NHT≤6개월적체적분별축소지76?59％급85?46％（ P＝0?001），이＞6개월자상근。결론 NHT시간월장，방료중전렬선체적급각방향직경변화폭도월소。중저위전렬선암환자NHT4개월이후전렬선체적적변화폭도교소，고위혹국부진전기환자NHT시간6개월이후변화폭도교소。
Objective To study the relationship between changes in prostate volume and neoadjuvant hormone therapy ( NHT) duration in prostate cancer radiotherapy. Methods Fifty patients with prostate cancer who received NHT were enrolled in the study continuously. The diameters along the x?, y?, and z?axes of the prostate were measured, and the volume of prostate was calculated weekly during radiotherapy. The relationship of prostate volume reduction with NHT duration, prostate volume before radiotherapy, and prostate cancer risk groups was analyzed during radiotherapy. Results The prostate volume in all patients decreased after radiotherapy. Patients with short NHT duration had larger changes in prostate volume and diameters than those with long NHT duration. Compared with those with a large prostate volume, patients with a normal prostate volume had larger changes in prostate volume and diameters long three axes after 7 weeks of radiotherapy, shorter NHT duration before radiotherapy, and lower risk of prostate cancer. In patients with low?and medium?risk prostate cancer, the prostate volumes were significantly reduced to 68?10% and 78?70%, respectively, of those before radiotherapy after no more than 4 months of NHT ( P=0?002) , but remained similar after more than 4 months of NHT. In patients with high?risk and more severe prostate cancer, the prostate volumes were significantly reduced to 76?59% and 85?46%, respectively, of those before radiotherapy after no more than 6 months of NHT (P=0?001), but remained similar after more than 6 months of NHT. Conclusions The changes in prostate volume and diameters along three axes during radiotherapy become smaller with longer NHT duration. Patients with low?or medium?risk prostate cancer have slight changes in prostate volume after more than 4 months of NHT, while patients with high?risk or locally advanced prostate cancer have slight changes in prostate volume after more than 6 months of NHT.